66557-23-1Relevant academic research and scientific papers
Preparation method of alkyl nitrile compound
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, (2020/05/14)
The invention discloses a preparation method of an alkyl nitrile compound shown as formula I. The preparation method comprises the following step: in a solvent, in the presence of an additive and a catalyst, Zn (CN) 2 and an alkyl halide shown as formula II are subjected to a coupling reaction as shown in the specification to obtain the alkyl nitrile compound as shown in the formula I, wherein theadditive comprises an alkali, the catalyst comprises a nickel compound and a phosphine ligand; the nickel compound is one or more of zero-valent nickel, monovalent nickel salt and divalent nickel salt; when the nickel compound contains zero-valent nickel or divalent nickel salt, the catalyst further comprises a reducing agent. According to the preparation method disclosed by the invention, cyanation of an alkyl halide can be simply, conveniently and efficiently realized by using a cheap catalytic system, and the preparation method also has good functional group compatibility and substrate universality.
REACTION OF HOMOALLYLIC COMPOUNDS OF TIN WITH ACYLATING AGENTS
Ivashchenko, N. B.,Polunin, E. V.,Kashin, A. N.
, p. 546 - 550 (2007/10/02)
In the reaction of homoallylic organotin compounds with carboxylic acid anhydrides and chlorides in the presence of Lewis acids cyclopropyl methyl ketones are formed with α,β-unsaturated ketones and β-chloro ketones as impurities.The ratio of the reaction products depends on the temperature, the structure of the reagents, and the type of catalyst.
Acylation du (cyclopropylmethyl)trimethylsilane. Une nouvelle voie d'acces aux enones non conjuguees
Grignon-Dubois, M.,Dunogues, J.,Calas, R.
, p. 802 - 806 (2007/10/02)
Acylation of (cyclopropylmethyl)trimethylsilane using RCOCl/AlCl3 (R: saturated hydrocarbon group) constitutes a mild, convenient route to β,γ-unsaturated ketones free from the conjugated isomers.With α,β-unsaturated acyl chlorides a competitive reaction between the C-H and C-Si allylic cleavage is observed whereas chloroacetyl chloride affords the γ,δ-ethylenic corresponding ketone.A mechanism involving the catalytic role of HCl in the formation of β,γ-unsaturated and chloroketones is proposed.
