6656-84-4Relevant academic research and scientific papers
Nucleophilic Substitutions of Alcohols in High Levels of Catalytic Efficiency
Stach, Tanja,Dr?ger, Julia,Huy, Peter H.
supporting information, p. 2980 - 2983 (2018/05/28)
A practical method for the nucleophilic substitution (SN) of alcohols furnishing alkyl chlorides, bromides, and iodides under stereochemical inversion in high catalytic efficacy is introduced. The fusion of diethylcyclopropenone as a simple Lewis base organocatalyst and benzoyl chloride as a reagent allows notable turnover numbers up to 100. Moreover, the use of plain acetyl chloride as a stoichiometric promotor in an invertive SN-type transformation is demonstrated for the first time. The operationally straightforward protocol exhibits high levels of stereoselectivity and scalability and tolerates a variety of functional groups.
(Hetero)aroyl esters of 2-(N-phthalimido)ethanol and analogues: Parallel synthesis, anti-HIV-1 activity and cytotoxicity
Cesarini, Sara,Spallarossa, Andrea,Ranise, Angelo,Schenone, Silvia,La Colla, Paolo,Collu, Gabriella,Sanna, Giuseppina,Loddo, Roberta
experimental part, p. 311 - 336 (2011/02/25)
The structural simplification of the non-nucleoside reverse transcriptase inhibitors (NNRTIs) O-(2-phthalimidoethyl)-N-(hetero)aroyl-N-arylthiocarbamates led us to design (hetero)aroyl esters of 2-(N-phthalimido)ethanol as a potential new class of anti-HI
