66584-72-3 Usage
Description
Ansamitocin P 3 is a macrocyclic antitumor antibiotic that works by depolymerizing microtubules in both interphase and mitosis, and perturbs chromosome segregation.
Definition
ChEBI: A polyketide antibiotic that is isolated from Actinosynnema pretiosum and also exhibits antitumour activity.
Check Digit Verification of cas no
The CAS Registry Mumber 66584-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,8 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66584-72:
(7*6)+(6*6)+(5*5)+(4*8)+(3*4)+(2*7)+(1*2)=163
163 % 10 = 3
So 66584-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10-
66584-72-3Relevant articles and documents
PREPARATION OF MAYTANSINOID ESTERS
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Paragraph 0444; 0445, (2014/07/08)
Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.
Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones
Akimoto,Kawai,Hashimoto,Nomura
, p. 2565 - 2570 (2007/10/02)
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