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Ansamitocin P-3 is a macrocyclic antitumor antibiotic that is isolated from Actinosynnema pretiosum. It is a polyketide antibiotic that works by depolymerizing microtubules in both interphase and mitosis, and perturbs chromosome segregation.
Used in Pharmaceutical Industry:
Ansamitocin P-3 is used as an antitumor agent for its ability to depolymerize microtubules and perturb chromosome segregation, making it a potential candidate for cancer treatment.
Used in Cancer Research:
Ansamitocin P-3 is used as a research tool for studying the mechanisms of microtubule depolymerization and chromosome segregation in cancer cells, which can help in the development of new cancer therapies.

66584-72-3

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66584-72-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 66584-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,8 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66584-72:
(7*6)+(6*6)+(5*5)+(4*8)+(3*4)+(2*7)+(1*2)=163
163 % 10 = 3
So 66584-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10-

66584-72-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ansamitocin P3

1.2 Other means of identification

Product number -
Other names 2'-De(acetylmethylamino)-2'-methylmaytansine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66584-72-3 SDS

66584-72-3Relevant academic research and scientific papers

PREPARATION OF MAYTANSINOID ESTERS

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Paragraph 0444; 0445, (2014/07/08)

Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.

Method for the preparation of maytansinoid esters

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Page/Page column 4, (2008/06/13)

Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.

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