Products Categories
CAS No.: | 66584-72-3 |
---|---|
Name: | ansamitocin P-3 |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C32H43ClN2O9 |
Molecular Weight: | 635.154 |
Synonyms: | TAM-330;11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate;Maytansine, 2-de (acetylmethylamino)-2-methyl-;Antibiotic C15003P3;Maytansine,2'-de(acetylmethylamino)-2'- methyl-;MAYTANSINE DERIV;C 15003P3;Tam 330;2-De(acetylmethylamino)-2-methylmaytansine;Ansamitocin P3;C15003P3;4,24-Dioxa-9, 22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.;Maytansine, 2-de(acetylmethylamino)-2-methyl-;Antibiotic C 15003P3;Ansamitosin P3;Ansamitocin P 3; |
Density: | 1.29 |
Melting Point: | 190-192℃ |
Boiling Point: | 833.1°C at 760 mmHg |
Flash Point: | 457.7°C |
Hazard Symbols: | Xn |
Risk Codes: | 20/22-36/37/38 |
Safety: | 26-36 |
PSA: | 136.16000 |
LogP: | 4.71740 |
The Ansamitocin P3, with the CAS registry number 66584-72-3. It belongs to the product categories of medicines and drugs. This chemical's molecular formula is C32H43ClN2O9 and molecular weight is 635.14. Its systematic name is Maytansine,2'-de(acetylmethylamino)-2'-methyl-.
Physical properties about Ansamitocin P3 are:
(1)ACD/LogP: 4.674; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 4.67; (4)ACD/LogD (pH 7.4): 4.67; (5)ACD/BCF (pH 5.5): 2101.74; (6)ACD/BCF (pH 7.4): 2095.43; (7)ACD/KOC (pH 5.5): 8315.59; (8)ACD/KOC (pH 7.4): 8290.63; (9)#H bond acceptors: 11; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 6; (12)Index of Refraction: 1.583; (13)Molar Refractivity: 163.432 cm3; (14)Molar Volume: 488.827 cm3; (15)Surface Tension: 54.992000579834 dyne/cm; (16)Density: 1.299 g/cm3; (17)Flash Point: 457.658 °C; (18)Enthalpy of Vaporization: 126.905 kJ/mol; (19)Boiling Point: 833.125 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C;
You can still convert the following datas into molecular structure:
(1)SMILES:O=C1O[C@H]4C[C@@](O)(N1)[C@H](OC)/C=C/C=C(/C)Cc2cc(c(Cl)c(OC)c2)N(C(=O)C[C@H](OC(=O)C(C)C)[C@@]3(O[C@H]3[C@@H]4C)C)C;
(2)Std. InChI:InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10-/t19-,23+,24-,25+,28+,31+,32+/m1/s1;
(3)Std. InChIKey:OPQNCARIZFLNLF-DQJFBWACSA-N;
The toxicity data of Ansamitocin P3 as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LDLo | intraperitoneal | 625ug/kg (.625mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #78-130495, |