6660-10-2Relevant academic research and scientific papers
Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives
He, Yuan,Liao, Xian-Zhang,Dong, Lin,Chen, Fen-Er
, p. 561 - 567 (2021/02/06)
Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.
Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides
Safrygin, Alexander,Dar'in, Dmitry,Lukin, Alexei,Bakholdina, Anna,Sapegin, Alexander,Krasavin, Mikhail
, p. 777 - 779 (2019/02/13)
The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aroma
Erratum to “Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides” (Tetrahedron Letters (2019) 60(11) (777–779), (S0040403919301182), (10.1016/j.tetlet.2019.02.011))
Safrygin, Alexander,Dar'in, Dmitry,Lukin, Alexei,Bakholdina, Anna,Sapegin, Alexander,Krasavin, Mikhail
, p. 1397 - 1398 (2019/05/07)
The publisher regrets that Tables 1 and 2 in the published article do not appear in the correct format. The tables have been corrected in the online article and can be seen here: The publisher would like to apologise for any inconvenience caused.
Base-Promoted Cycloisomerization for the Synthesis of Oxazoles and Imidazoles
Zhang, Lidan,Xiao, Ke,Qiao, Yan,Li, Xin,Song, Chuanjun,Chang, Junbiao
, p. 6913 - 6918 (2018/12/05)
Treatment of propargylamides or propargylamidines with cesium carbonate in DMSO results in the formation of the corresponding oxazoles or imidazoles in good yields. A large variety of substrates with various functional groups are tolerated. DFT study on a model substrate reveals that the reactions proceed via a sequence involving allene formation, intramolecular cyclization, and double-bond isomerization.
Synthesis of oxazoles through Pd-catalyzed cycloisomerization-allylation of N-propargylamides with allyl carbonates
Saito, Akio,Iimura, Koichi,Hanzawa, Yuji
scheme or table, p. 1471 - 1474 (2010/04/29)
In the presence of Pd2(dba)3-Cy3P catalyst, IPr·HCl salt [IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], and Cs2CO3, N-propargylamides react with allyl carbonates to give 2,5-disubstituted o
