6661-54-7

Basic information

• Product Name: 2-butoxyethyl tosylate
• Synonyms: 2-butoxyethyl tosylate;NSC 312014;4-Methylbenzenesulfonic acid 2-butoxyethyl ester
• CAS NO: 6661-54-7
• Molecular Formula: C₁₃H₂₀O₄S
• Molecular Weight: 272.3605
• EINECS: 229-703-2
• Mol File: 6661-54-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 384.7°Cat760mmHg
• Flash Point: 186.4°C
• Appearance: /
• Density: 1.122g/cm³
• Vapor Pressure: 8.9E-06mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: 2-butoxyethyl tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butoxyethyl tosylate(6661-54-7)
• EPA Substance Registry System: 2-butoxyethyl tosylate(6661-54-7)

Safety Data

• Hazardous Substances Data: 6661-54-7(Hazardous Substances Data)

Usage

General Description

2-butoxyethyl tosylate is a chemical compound that is commonly used as a reagent in organic synthesis. It is often utilized as a tosylating agent, meaning it can be used to convert alcohols and phenols into their corresponding tosylates. Tosylates are a versatile class of compounds that have many applications in organic chemistry, including as intermediates in the synthesis of pharmaceuticals and other fine chemicals. 2-butoxyethyl tosylate is a clear, colorless liquid with a mild odor, and it is considered to be a relatively safe reagent to handle when used in a controlled manner. However, as with any chemical, proper handling and storage procedures should always be followed to ensure safety.

InChI:InChI=1/C13H20O4S/c1-3-4-9-16-10-11-17-18(14,15)13-7-5-12(2)6-8-13/h5-8H,3-4,9-11H2,1-2H3

Upstream product

• 111-76-2 2-Butoxyethanol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 63735-44-4 4-(2-butoxyethoxy)benzaldehyde 
• 187748-44-3 2-n-butoxyethyl 2-benzyloxy-6-naphthoate 
• 158937-13-4 1-carbomethoxy-4'-<<4-<<(n-butyloxy)ethyl>oxy>phenyl>ethynyl>biphenyl 
• 98654-34-3 (4-Acetamino-2-propionyl-phenyl)-(2-butyloxy-ethyl)-ether 
• 4863-06-3 3-Jod-5-butoxycarbonyl-benzoesaeure-(2-butoxy-aethylester) 
• 4862-99-1 3-Jod-5-propoxycarbonyl-benzoesaeure-(2-butoxy-aethylester) 
• 4842-20-0 3-Jod-5-aethoxycarbonyl-benzoesaeure-(2-butoxy-aethylester) 
• 4842-12-0 3-Jod-5-methoxycarbonyl-benzoesaeure-(2-butoxy-aethylester) 
• 54645-60-2 2-(2-Butoxy-ethoxy)-5-(2-dibenzylamino-acetyl)-benzamide 

Relevant articles and documents

MANUFACTURING METHOD OF 1,1-DISUBSTITUTED HYDRAZINE COMPOUND

PROBLEM TO BE SOLVED: To provide a manufacturing method of a 1,1-disubstituted hydrazine compound useful as a manufacturing intermediate. SOLUTION: There is provided a manufacturing method of a 1,1-disubstituted hydrazine compound represented by the formula (3) by reacting a hydrazino compound represented by the formula (1) with a compound represented by the formula (2): R-A in the presence of a correlation transfer catalyst, and a base such as alkali metal hydroxide, alkali earth metal hydroxide, and alkali metal alkoxide in a mixed solvent of water and a water insoluble organic solvent. In the formula, Q represents O, S or the like; R represents a C1 to 12 organic group which may have a substituent; A represents Cl, Br, a tosyl group or the like; Ra1 to Ra4 each independently represent H, a halogen atom, a C1 to 6 alkyl group, or the like. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Rapid transformation of sulfinate salts into sulfonates promoted by a hypervalent iodine(III) reagent

An alternative method for forming sulfonates through hypervalent iodine(III) reagent-mediated oxidation of sodium sulfinates has been developed. This transformation involves trapping reactive sulfonium species using alcohols. With additional optimization of the reaction conditions, the method appears extendable to other nucleophiles such as electron-rich aromatic systems or cyclic ethers through a ring opening pathway.

Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors

A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC50 = 1.22 mM). Interestingly, compound 3c bearing a dimethoxyl phosphate was found to be the most potent inhibitor with IC50 value of 0.059 mM. The inhibition kinetics analyzed by Lineweaver-Burk plots revealed that compound 3c was a non-competitive inhibitor (KI = 0.0368 mM). In particular, compound 3c showed no side effects at dose of 1600 mg/kg in mice. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors.