66618-79-9Relevant academic research and scientific papers
Enzymatic synthesis of optical pure β-nitroalcohols by combining d-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution
Xu, Fan,Wang, Junliang,Liu, Bokai,Wu, Qi,Lin, Xianfu
, p. 2359 - 2361 (2011/10/19)
An enzymatic method which combines d-aminoacylase catalyzed nitroaldol reaction and lipase PS-IM catalyzed acyl resolution reaction was constructed to obtain optically pure β-nitroalcohols in organic media under mild conditions. A series of β-nitroalcohols were synthesized and then resolved, with excellent ee values (>95%) and yields mostly, giving enantiomerically pure acetate and alcohol of the opposite configuration simultaneously.
