666259-62-7

Upstream product

• 556-56-9 allyl iodid 
• 666259-61-6 (4S)-3-[3-(5-methylindol-1-yl)propanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 18108-86-6 3-(5-methylindol-1-yl)propanoic acid 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 

Downstream Products

• 666259-68-3 tert-butyl 3-[N-({N-[1-(N-{(2R)-2-[(5-methylindol-1-yl)methyl]pent-4-enyl}carbamoyl)(1S)-2-carbamoylethyl]carbamoyl}cyclohexyl)carbamoyl](3S,4S)-4-(4-{[bis(tert-butoxy)carbonyl]methyl}phenyl)hept-6-enoate 
• 666259-69-4 tert-butyl 2-[(9S,10S,18S,14R)-7,16,19-triaza-10-(4-{[bis(tert-butoxy)carbonyl]methyl}phenyl)-18-carbamoylmethyl-14[(5-methylindol-1-yl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl]acetate 
• 637332-52-6 2-{(9S,10S,14R,18S)-7,16,19-triaza-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxo-10-[4-(phosphonomethyl)phenyl]spiro[5.14]icos-11-en-9-yl}acetic acid 
• 666259-67-2 N-{(2R)-2-[(5-methylindol-1-yl)methyl]pent-4-enyl}(2S)-2-[(aminocyclohexyl)carbonylamino]-3-carbamoylpropanamide 

Relevant academic research and scientific papers

Synthesis of a 5-Methylindolyl-Containing Macrocycle That Displays Ultrapotent Grb2 SH2 Domain-Binding Affinity

The growth factor receptor-bound protein 2 (Grb2) is an SH2 domain-containing docking module that represents an attractive target for anticancer therapeutic intervention. Here, a ring-closing metathesis approach is utilized to synthesize a 5-methylindolyl