66643-66-1

Upstream product

• 31785-72-5 1-methyl-2-pyrrolyllithium 
• 96-54-8 N-Methylpyrrole 
• 536-74-3 phenylacetylene 
• 3240-11-7 Phenylacetylene-d1 
• 98-86-2 acetophenone 

Downstream Products

• 66643-69-4 3-methyl-4-phenyl-3H-naphth<2.3-e>indole-6,11-dione 
• 94633-39-3 dimethyl 6,7-dihydro-1-methyl-7-phenylindole-4,5-dicarboxylate 
• 94633-38-2 dimethyl <1-methyl-5-(1-phenylethenyl)pyrrol-2-yl>fumarate 
• 94633-37-1 dimethyl <1-methyl-5-(1-phenylethenyl)pyrrol-2-yl>maleate 
• 1159420-78-6 1,1-bis(1-methyl-1H-pyrrol-2-yl)-1-phenylethane 
• 1373766-62-1 1-(1H-pyrrol-2-yl)-1-(1-methylpyrrol-2-yl)-1-phenylethane 
• 1373766-63-2 1-methyl-2,5-bis(1-phenylethenyl)-pyrrole 
• 66643-71-8 3-methyl-4-phenylanthra<2,1-b>pyrrole 

Relevant academic research and scientific papers

Gold(I) Complexes in Ionic Liquids: An Efficient Catalytic System for the C-H Functionalization of Arenes and Heteroarenes under Mild Conditions

Use of ionic liquids bearing the proper counteranion as reaction solvents allows to boost the reactivity of gold(I) complexes as catalysts in the hydroarylation of alkynes with arenes and heteroarenes. Several commercial complexes of general structure LAu

The Gold-Catalyzed Hydroarylation of Alkynes with Electron-Rich Heteroarenes – A Kinetic Investigation and New Synthetic Possibilities

The gold-catalyzed mono-hydroarylation and two-fold hydroarylation of alkynes with electron-rich heteroarenes was analyzed by a1H NMR kinetic study. The obtained rate constants for the decreasing alkyne concentration provide information on the reactivity of this addition reaction. The examinations show the orthogonal reactivity of gold and a proton for the two reaction steps. The first hydroarylation is exclusively promoted by gold(I), whereas the second step is premised on a proton which will be reversibly derived from the formation of σ,π-acetylide complexes from the terminal alkynes or by interaction with solvents. Based on kinetic data, it was possible to synthesize a large range of mono-adducts in moderate to good yields, furthermore the synthesis of hetero-di-adducts, bearing two different substituents, was explored. (Figure presented.).

Addition of pyrroles onto terminal alkynes catalyzed by a dinuclear ruthenium (II) complex

The addition of pyrroles onto alkynes has been catalyzed by a dinuclear ruthenium complex, Ru2(CO)4(PPh3)2Br4, resulting in the formation of geminal 2-vinylpyrroles in high yields under mild conditions. Further functionalization with pyrroles or alkynes to afford dipyrrolmethanes or 2,5-bis(vinyl)pyrroles via the vinyl functional group can readily be achieved. A mechanism involving cationic ruthenium complexes was proposed based on the product regioselectivity, deuteration and infrared spectroscopic studies carried out on the catalytic process.