66645-63-4Relevant academic research and scientific papers
Design, synthesis, pharmacological evaluation, in silico modeling, prediction of toxicity and metabolism studies of novel 1-(substituted)-2-methyl- 3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas
Sulthana,Alagarsamy,Chitra
, p. 352 - 368 (2021/03/08)
Background: Although exhaustive efforts to prevent and treat tuberculosis (TB) have been made, the problem still continues due to multi-drug-resistant (MDR) and extensively drugresistant TB (XDR-TB). It clearly highlights the urgent need to develop novel
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.
Alagarsamy, Veerachamy,Salomon, Viswas Raja,Vanikavitha, Gnanavel,Paluchamy, Veeran,Chandran, Muniyandi Ravi,Sujin, Augustin Arnald,Thangathiruppathy, Arunachalam,Amuthalakshmi, Sivaperuman,Revathi, Rajappan
, p. 1432 - 1435 (2007/10/03)
A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic ac
Synthesis of 2,3-disubstituted-3,1-quinazolin-4(4H)-ones as potential anticancer and anti-HIV agents
Shah, B. R.,Bhatt, J. J.,Patel, H. H.,Undavia, N. K.,Trivedi, P. B.,Desai, N. C.
, p. 201 - 208 (2007/10/02)
Several 3-(4,5-dihydro-4-arylidine-5-oxo-2-phenyl-1H-imidazol-1-yl)-2-phenyl-4(3H)-oxoquinazolines (4a-l), -N-substituted-arylacetamides (5a-n), N1-aminocarbonylphenyl>-N2-alkyl/arylthioureas (7a-h), N12-arylthioureas (8a-l) and N1-aminocarbophenyl>-N2-carboaryl/aryloxythioureas (11a-h) have been synthesized and tested for their asntibacterial, antitubercular, anticancer and anti-HIV activities.The structures of these compounds have been established on the basis of elemantal analyses and spectral data.
SYNTHESIS OF SOME 3-SUBSTITUTED 4(3H)-QUINAZOLINONE AND 4(3H)-QUINAZOLINETHIONE DERIVATIVES AND RELATED FUSED BIHETEROCYCLIC RING SYSTEMS
Abdel-Megeed, Mohamed Farghali,Teniou, Abderrahman
, p. 329 - 335 (2007/10/02)
The reactions of 2-phenyl-4(3H)-quinazolinone, 2-phenyl-3-amino-4(3H)-quinazolinone, and corresponding thiones with phenyl isocyanate or phenyl isothiocyanate were investigated.The resulting urea and thiourea quinazoline or quinazolinethione derivatives r
