66662-88-2

Upstream product

• 39621-09-5 2,6-dihydroxy-4-phenyl-3-cyano-pyridine 
• 98-86-2 acetophenone 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 110-91-8 morpholine 
• 37860-86-9 2,6-dihydroxy-4-phenylnicotinonitrile 

Downstream Products

• 66663-85-2 1-benzyl-6-morpholin-4-yl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 66663-35-2 6-morpholin-4-yl-4-phenyl-1⁽²⁾H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 66663-39-6 1-methyl-6-morpholin-4-yl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine 

Relevant academic research and scientific papers

The guareschi pyridine scaffold as a valuable platform for the identification of selective PI3K inhibitors

A novel series of 4-aryl-3-cyano-2-(3-hydroxyphenyl)-6-morpholino-pyridines have been designed as potential phosphatidylinositol-3-kinase (PI3K) inhibitors. The compounds have been synthesized using the Guareschi reaction to prepare the key 4-aryl- 3-cyano-2,6-dihydroxypyridine intermediate. A different selectivity according to the nature of the aryl group has been observed. Compound 9b is a selective inhibitor against the PI3Kα isoform, maintaining a good inhibitory activity. Docking studies were also performed in order to rationalize its profile of selectivity.

3-Amino-4-phenyl-6-piperidino-1H-pyrazolo[3,4-b]-pyridines and salts thereof

Compounds of the formula STR1 wherein R1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl; R2 is hydr

3-Amino-4-phenyl-1H-pyrazolo[3,4-b]pyridines and salts thereof

Compounds of the formula STR1 wherein R1 is mono- or di-substituted amino, where the substituents are selected from the group consisting of alkyl of 1 to 6 carbon atoms, cyclohexyl, allyl and benzyl; unsubstituted, mono-substituted or di-substi