6670-16-2

Usage

Type of compound

heterocyclic organic compound

Contains

a benzoxazole ring and a thione group

Usage

in the synthesis of pharmaceuticals and agrochemicals, potential applications in materials science

Unique

structure and properties that make it useful in various chemical reactions and as a building block for new molecules with diverse functionalities

Potential

biological activities, area of interest for further study in medicinal chemistry.

Upstream product

• 75-15-0 carbon disulfide 
• 6946-05-0 2-aminocyclohexanone hydrochloride 

Relevant academic research and scientific papers

ALKYLAMINOPYRIDINE DERIVATIVE

The present invention relates to a compound that is useful for treatment of, for example, hypertension, arteriosclerosis, bulimia and obesity because of having an antagonistic action to a neuropeptide Y receptor and is represented by formula (I) [wherein R1 represents hydrogen, cyano, or the like; R represents a group represented by formula (II); X1 represents C1-4 lower alkylene or the like; X2 represents lower alkylene or the like; and Het represents a 5-membered heteroaromatic ring that has at least one nitrogen atom and, in addition, one or two hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms] or to a pharmaceutically acceptable salt thereof.

SYNTHESIS AND STABILITY OF 2-OXOISOTHIOCYANATES

Enolizable 2-oxoisothiocyanates Ia-If were prepared from hydrochlorides of amino ketones, containing a hydrogenatom in the α-position, by reaction with thiophosgene in the presence of CaCO3.At room temperature the enol form of these compounds undergoes slow cyclization to give the isomeric 4-oxazoline-2-thiones IIb-IIf.In the presence of bases this isomerization proceeds rapidly even at room temperature. 2-Isothiocyanatocyclopentanone (Ia) does not cyclize to the corresponding oxazolinethione either on heating or action of bases.The rate of the thermally initiated isomerization of the 2-oxoisothiocyanates Ib-If was determined by IR spectroscopy.