6946-05-0

Basic information

• Product Name: 2-aminocyclohexanone hydrochloride
• Synonyms: 2-aminocyclohexanone hydrochloride;2-Aminocyclohexanone hcl;Cyclohexanone,2-amino-, hydrochloride
• CAS NO: 6946-05-0
• Molecular Formula: C₆H₁₁NO*ClH
• Molecular Weight: 149.61858
• Mol File: 6946-05-0.mol

Chemical Properties

• Melting Point: 157-158 °C (decomp)
• Boiling Point: 213.9 °C at 760 mmHg
• Flash Point: 83.2 °C
• Appearance: /
• Density: 1.023g/cm³
• Vapor Pressure: 0.16mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-aminocyclohexanone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aminocyclohexanone hydrochloride(6946-05-0)
• EPA Substance Registry System: 2-aminocyclohexanone hydrochloride(6946-05-0)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-51/53
• Hazardous Substances Data: 6946-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
2-aminocyclohexanone hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential role in the treatment of neurological disorders. Its unique structure allows for the development of new medications that can target specific neurological conditions more effectively.
Used in Organic Synthesis:
In the field of organic synthesis, 2-aminocyclohexanone hydrochloride is used as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and the presence of both the cyclohexanone ring and the amino group make it a valuable component in the synthesis of complex organic molecules.
Used in Laboratory Applications:
The hydrochloride form of 2-aminocyclohexanone provides enhanced solubility and stability, making it suitable for various laboratory applications. Researchers can utilize this compound in their experiments to study its properties and explore its potential uses in different chemical reactions and processes.

InChI:InChI=1/C6H11NO/c7-5-3-1-2-4-6(5)8/h5H,1-4,7H2

Upstream product

• 108-91-8 cyclohexylamine 
• 4883-67-4 2-nitrocyclohexanone 
• 108-94-1 cyclohexanone 
• 171974-66-6 2,4,5,6,7,7a-Hexahydro-1H-benzimidazole-2-spiro-1'-cyclohexane 

Downstream Products

• 89849-11-6 4,5,6,7-tetrahydro-3H-benzoxazol-2-one 
• 24467-23-0 1,3,4,5,6,7-hexahydro-benzoimidazole-2-thione 
• 26258-21-9 2,3,4,5,6,7-Hexahydro-1H-benzimidazol-2-on 
• 4006-50-2 1,2,3,4,6,7,8,9-octahydrophenazine 
• 3400-45-1 cyclopentanecarboxylic acid 
• 40814-51-5 2-formylamino-cyclohexanone 
• 4450-39-9 ethyl 5-cyanovalerate 
• 1120-73-6 2-methyl-2-cyclopenten-1-one 
• 4160-49-0 bicyclo[3.1.0]hexan-2-one 
• 4340-74-3 α-Amino-cyclohexanon-trans-oxim 
• 5551-02-0 α-Trityl-amino-cyclohexanon 
• 35077-41-9 α-chloroacetamidocyclohexanone 
• 130510-63-3 2-mercapto-1-(2-pyridyl)-4,5,6,7-tetrahydrobenzimidazole 
• 60511-85-5 11,12-dihydroindolo[2,3-a]carbazole 

Relevant articles and documents

One-Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp3 C?H Imination

The direct replacement of sp3 C?H bonds with simple amine units (?NH2) remains synthetically challenging, although primary aliphatic amines are ubiquitous in medicinal chemistry and natural product synthesis. We report a mild and selective protocol for preparing primary and secondary aliphatic amines in a single pot, based on intermolecular sp3 C?H imination. The first C?H imination of diverse alkanes, this method shows useful site-selectivity within substrates bearing multiple sp3 C?H bonds. Furthermore, this reaction tolerates polar functional groups relevant for complex molecule synthesis, highlighted in the synthesis of amine pharmaceuticals and amination of natural products. We characterize a unique C?H imination mechanism based on radical rebound to an iminyl radical, supported by kinetic isotope effects, stereoablation, resubmission, and computational modeling. This work constitutes a selective method for complex amine synthesis and a new mechanistic platform for C?H amination.

6-SUBSTITUTED- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R? N-R" R* where R6 is -(CrC3)alkyl-S-(C0-C3)alkyl-R10, -(C1-C3)alkyl-NR11R12, -(CrC3)alkyl-O- R 13. and other substituents are as defined in the specification.

Electrolytic Oxidation of Ketones in Ammoniacal Methanol in the Presence of Catalytic Amounts of KI

The indirect electrooxidation of ketones in ammoniacal methanol using iodide ion as a mediator afforded 2,2-dialkyl-2,5-dihydro-1H-imidazoles 3 via an oxidative cyclocoupling of ketimine intermediates formed from ketones and ammonia.The treatment of 3 with dilute HCl gave α-amino ketone hydrochlorides 4 and the parent ketones in good yields.A similar electrooxidation of 3 resulted in the formation of the corresponding 2H-imidazoles 6, which were hydrolyzed to α-diketones and the parent ketones.The same products 6 could also conveniently be obtained by chemical oxidation of 3 with aqueous NaOCl.

SYNTHESIS OF α-AMINO KETONE HYDROCHLORIDES VIA CHEMOSELECTIVE HYDROGENATION OF α-NITRO KETONES

Chemoselective hydrogenation of various α-nitro ketones was accomplished with 5percent Pt sulfide on carbon as a catalyst to afford α-amino ketone hydrochlorides in good yields.