66735-02-2

Upstream product

• 619-23-8 3-Nitrobenzyl chloride 
• 86096-97-1 diethyl methyl-(3-nitrobenzyl)malonate 
• 29417-82-1 2-methyl-3-(3-nitrophenyl)-propionic acid methyl ester 

Downstream Products

• 66735-02-2 (R)-2-(3-nitrobenzyl)propionic acid 
• 98709-79-6 3-(3-acetamido-phenyl)-2-methylpropionic acid 
• 138809-59-3 (R)-2-methyl-3-(3-nitro-phenyl)-propionic acid methyl ester 
• 41201-56-3 (R)-3-(3-amino-phenyl)-2-methyl-propionic acid 
• 138711-97-4 (S)-(+)-2-(3-nitrobenzyl)propionic acid 
• 138711-93-0 methyl 3-aminophenyl-2-methylpropionate 
• 29417-82-1 2-methyl-3-(3-nitrophenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor

The present invention provides a compound of formula (I): wherein: R1 is a group selected from -CH2OH,-NHCOH and R2 is a hydrogen atom; or R1 together with R2 form the group -NHC(O)CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2, R3a and R3b are independently selected from the group consisting of hydrogen atoms and C1-4 alkyl groups n is an integer selected from 0 to 6, R4 is selected from the group consisting of an optionally substituted monocyclic or polycyclic C3-10 cycloalkyl group, an optionally substituted monocyclic C5-10 aryl group and, a methyl group which is substituted with one or more substituents selected from C5-10 aryl and C5-10 aryloxy groups, wherein the monocyclic or polycyclic C3-10 cycloalkyl and the monocyclic C5-10 aryl groups independently are optionally substituted with one or more substituents selected from halogen atoms, C1-4 alkyl, C1-4 alkoxy, C5-10 aryl and C5-10 aryloxy groups, or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

CHEMOENZYMATIC SYNTHESIS OF THE ENANTIOMERS OF IOPANOIC ACID

The two enantiomers of Iopanoic acid 1 were prepared in enantiomeric excess higher than 90percent by enzyme-catalyzed hydrolysis of precursors (+/-)-2a and (+/-)-3a, followed by standard chemical transformations.Among the tested enzymes, chymotrypsin and Lipase PS proved to be the most selective catalysts.The stereochemical outcome of the lipase-catalyzed hydrolyses of esters (+/-)-2a-d is strictly dependent upon both the size of the alkyl group attached to the chiral center and the substituent in the aromatic ring.The enantioselectivity of the reactions was evaluated by chiral HPLC and the configurations of the new products were assigned by chemical correlations.