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α-Methyl-4-(1-methylethyl)benzenepropanoic acid, also known as 3-phenylpropionic acid or hydrocinnamic acid, is an organic compound with the chemical formula C10H12O2. It is a colorless to pale yellow crystalline solid that is soluble in water, ethanol, and ether. α-Methyl-4-(1-methylethyl)benzenepropanoic acid is a derivative of benzene with a propionic acid side chain, where the propionic acid group is attached to the para position of the benzene ring, and the isopropyl group is attached to the alpha carbon of the propionic acid chain. It is widely used in the synthesis of pharmaceuticals, fragrances, and flavorings due to its aromatic properties and versatile chemical structure.

66735-06-6

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66735-06-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 66735-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,7,3 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 66735-06:
(7*6)+(6*6)+(5*7)+(4*3)+(3*5)+(2*0)+(1*6)=146
146 % 10 = 6
So 66735-06-6 is a valid CAS Registry Number.

66735-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name p-isopropyl-α-methyl-hydroxycinnamic acid

1.2 Other means of identification

Product number -
Other names 3-(4-isopropylphenyl)-2-methylpropanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66735-06-6 SDS

66735-06-6Relevant academic research and scientific papers

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

Wang, Zhi-Gang,Chen, Liqun,Chen, Jiebo,Zheng, Jian-Feng,Gao, Weiwei,Zeng, Zhiping,Zhou, Hu,Zhang, Xiao-Kun,Huang, Pei-Qiang,Su, Ying

, p. 632 - 648 (2013/05/09)

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.

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