3602-26-4

Basic information

• Product Name: 2-Propenoicacid,2-methyl-3-[4-(1-methylethyl)phenyl]-(9CI)
• Synonyms: 2-Propenoicacid,2-methyl-3-[4-(1-methylethyl)phenyl]-(9CI)
• CAS NO: 3602-26-4
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.26494
• Product Categories: PHENYL
• Mol File: 3602-26-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoicacid,2-methyl-3-[4-(1-methylethyl)phenyl]-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoicacid,2-methyl-3-[4-(1-methylethyl)phenyl]-(9CI)(3602-26-4)
• EPA Substance Registry System: 2-Propenoicacid,2-methyl-3-[4-(1-methylethyl)phenyl]-(9CI)(3602-26-4)

Safety Data

• Hazardous Substances Data: 3602-26-4(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 516-05-2 methyl-propanedioic acid 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 137104-36-0 2-[Hydroxy-(4-isopropyl-phenyl)-methyl]-acrylic acid methyl ester 
• 220778-69-8 methyl 3-acetoxy-3-(4-isopropylphenyl)-2-methylenepropanoate 
• 10034-85-2 hydrogen iodide 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 1346513-45-8 C₂₅H₂₈O₂ 
• 66735-06-6 p-isopropyl-α-methyl-hydroxycinnamic acid 
• 27319-06-8 1-(1-methylethyl)-4-(prop-1-en-1-yl)benzene 

Relevant articles and documents

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.

Preparation and biologic properties of α alkylcinnamic acids

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