667463-95-8 Usage
Description
1-METHYL-BIO, also known as MeBIO, is an indirubin compound that has been identified as a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. Its unique structure and inhibitory properties make it a promising candidate for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
1-METHYL-BIO is used as a therapeutic agent for targeting GSK3 and cyclin-dependent kinases, which play crucial roles in various cellular processes and diseases. Its inhibitory action on these kinases makes it a potential candidate for the treatment of disorders associated with their dysregulation, such as cancer and neurodegenerative diseases.
Used in Cancer Research:
1-METHYL-BIO is used as a research tool for studying the role of GSK3 and cyclin-dependent kinases in cancer development and progression. Its potent inhibitory effects on these kinases can help researchers understand their involvement in tumor growth, survival, and resistance to therapies, ultimately leading to the development of novel cancer treatments.
Used in Neurodegenerative Disease Research:
1-METHYL-BIO is used as a research compound for investigating the role of GSK3 in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Its inhibitory action on GSK3 can provide insights into the potential therapeutic benefits of targeting this kinase in the context of neuroprotection and disease modification.
Used in Drug Development:
1-METHYL-BIO is used as a lead compound in the development of new drugs targeting GSK3 and cyclin-dependent kinases. Its potent inhibitory properties and selectivity make it a valuable starting point for designing and optimizing novel therapeutic agents with improved efficacy, safety, and pharmacokinetic profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 667463-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,7,4,6 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 667463-95:
(8*6)+(7*6)+(6*7)+(5*4)+(4*6)+(3*3)+(2*9)+(1*5)=208
208 % 10 = 8
So 667463-95-8 is a valid CAS Registry Number.
667463-95-8Relevant articles and documents
INDIRUBIN-TYPE COMPOUNDS, COMPOSITIONS, AND METHODS FOR THEIR USE
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Page/Page column 27-29; Figure 2B, (2008/06/13)
Compounds and compositions including 6-bromo-indirubin, 5-amino-indirubin and N-methyl-indirubins and related indirubin derivatives are provided that are useful as selective modulators of glycogen synthase kinase-3, cyclin-dependent protein kinases or aryl hydrocarbon receptors. Methods of inhibiting or modulating cell growth or cell cycling are provided using the compounds of the invention. In other aspects, compounds and methods for the treatment of protozoan-mediated diseases, Alzheimer's disease and diabetes are provided.
