667463-64-1Relevant academic research and scientific papers
Ru(III)-mediated intramolecular ortho-C(sp2)-H activation/oxidative acylation: One-pot synthesis of isatins from α-hydroxy amides
Wang, Yaoling,Li, Weijian,Cheng, Xu,Zhan, Zhen,Ma, Xiaojun,Guo, Li,Jin, Hui,Wu, Yong
, p. 3193 - 3197 (2016/05/24)
A novel and efficient synthesis of isatins from α-hydroxy amides via ruthenium-mediated aromatic C-H activation is described. The reactions proceeded smoothly under mild conditions and generated the corresponding products in good to excellent yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the application of intramolecular ortho-C-H activation.
Hydrogen Peroxide Promoted Metal-Free Oxidation/Cyclization of α-Hydroxy N-Arylamides: A Facile One-Pot Synthesis of Isatins
Li, Jie,Cheng, Xu,Ma, Xiaojun,Lv, Guanghui,Zhan, Zhen,Guan, Mei,Wu, Yong
supporting information, p. 2485 - 2488 (2016/10/25)
A novel, efficient, and environmentally friendly method was developed for converting α-hydroxy N-arylamides into isatins (1H-indole-2,3-diones) by using hydrogen peroxide as oxidant. The reactions proceeded smoothly under metal-free conditions and generated the corresponding products in good to excellent yields. This method has advantages of a broad substrate scope and simple operations.
IBX-promoted domino reaction of α-hydroxy amides: A facile one-pot synthesis of isatins
Wang, Yaoling,Cheng, Xu,Zhan, Zhen,Ma, Xiaojun,Nie, Ruifang,Hai, Li,Wu, Yong
, p. 2870 - 2874 (2016/01/16)
A novel and temperature-controlled oxidation of α-hydroxy amides in the presence of IBX is described. The divergent one-pot synthesis of isatins and α-formyl amides was achieved in good to excellent yields under metal-free conditions. And these two mild methods can tolerate a variety of functional groups, and are operationally simple.
Synthesis of isatins by the palladium-catalyzed intramolecular acylation of unactivated aryl C(sp2)-H bonds
Li, Jue,Zheng, Yang,Yu, Xinling,Lv, Songyang,Wang, Qiantao,Hai, Li,Wu, Yong
, p. 103280 - 103283 (2015/12/23)
Synthesis of isatins from formyl-N-arylformamides is achieved via PdCl2-catalyzed intramolecular acylation. This method shows the possibility of Pd-catalyzed aryl C(sp2)-H bond activation on the synthesis of isatins, affording an array of isatins in good yields. Yet this protocol is operationally simple and atom economical.
