667463-64-1Relevant articles and documents
Ru(III)-mediated intramolecular ortho-C(sp2)-H activation/oxidative acylation: One-pot synthesis of isatins from α-hydroxy amides
Wang, Yaoling,Li, Weijian,Cheng, Xu,Zhan, Zhen,Ma, Xiaojun,Guo, Li,Jin, Hui,Wu, Yong
, p. 3193 - 3197 (2016/05/24)
A novel and efficient synthesis of isatins from α-hydroxy amides via ruthenium-mediated aromatic C-H activation is described. The reactions proceeded smoothly under mild conditions and generated the corresponding products in good to excellent yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the application of intramolecular ortho-C-H activation.
IBX-promoted domino reaction of α-hydroxy amides: A facile one-pot synthesis of isatins
Wang, Yaoling,Cheng, Xu,Zhan, Zhen,Ma, Xiaojun,Nie, Ruifang,Hai, Li,Wu, Yong
, p. 2870 - 2874 (2016/01/16)
A novel and temperature-controlled oxidation of α-hydroxy amides in the presence of IBX is described. The divergent one-pot synthesis of isatins and α-formyl amides was achieved in good to excellent yields under metal-free conditions. And these two mild methods can tolerate a variety of functional groups, and are operationally simple.