6678-00-8

Basic information

• Product Name: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate
• Synonyms: Valeric acid 11β,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester;Hydrocortisone 21-Valerate;XHDMDWMKAYYIRK-FZNHGJLXSA-N
• CAS NO: 6678-00-8
• Molecular Formula: C₂₆H₃₈O₆
• Molecular Weight: 446.5763
• EINECS: 229-716-3
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 6678-00-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 515.91°C (rough estimate)
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.0663 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• Water Solubility: 3.05mg/L(25 oC)
• CAS DataBase Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(CAS DataBase Reference)
• NIST Chemistry Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(6678-00-8)
• EPA Substance Registry System: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(6678-00-8)

Safety Data

• Hazardous Substances Data: 6678-00-8(Hazardous Substances Data)

Usage

Uses

Hydrocortisone 21-Valerate is a derivative of Hydrocortisone (H714615) a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Upstream product

• 50-23-7 HYDROCORTISONE 
• 2082-59-9 pentanoic anhydride 

Relevant articles and documents

Relative affinity of 17α-and/or 21-esters and 17α,21-diesters of cortisol for a glucocorticoid receptor from rat thymocytes

The affinity, relative to cortisol, of 17α- and 21-esters and 17α,21-diesters of cortisol for the glucocorticoid receptor of rat thymus cytosol was determined by a competitive binding assay which used [3H]dexamethasone. Esterification of the 21-hydroxy group of cortisol caused a loss of relative affinity to 0.046 for acetate and 0.32 for valerate. Esterification of the 17α-hydroxy group resulted in an increase in relative affinity to 1.14 for acetate, 12.4 for butyrate, and 11.5 for valerate. Diesters had relative affinities which reflected both trends. Thus, the 21-acetate, 21-propionate, 21-butyrate, and 21-valerate of cortisol 17-acetate had relative affinities of 0.036, 0.093, 0.152, and 0.272. The 21-acetate, 21-propionate, and 21-butyrate of cortisol 17-valerate had relative affinities of 0.76, 1.17, and 1.33.