66785-51-1

Basic information

• Product Name: 3,3a,4,5-tetrahydropyrrolo[1,2-a]quinolin-1(2H)-one
• CAS NO: 66785-51-1
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.2377
• Mol File: 66785-51-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 360.6°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.2g/cm³
• Vapor Pressure: 2.2E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 3,3a,4,5-tetrahydropyrrolo[1,2-a]quinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3a,4,5-tetrahydropyrrolo[1,2-a]quinolin-1(2H)-one(66785-51-1)
• EPA Substance Registry System: 3,3a,4,5-tetrahydropyrrolo[1,2-a]quinolin-1(2H)-one(66785-51-1)

Safety Data

• Hazardous Substances Data: 66785-51-1(Hazardous Substances Data)

Upstream product

• 1311146-08-3 5-iodo-4,5,6,7-tetrahydro-1H-benzo[b]azonin-2(3H)-one 
• 1311145-71-7 N-(2-(but-3-enyl)phenyl)-2-iodoacetamide 
• 68847-33-6 2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine 
• 612-25-9 2-Nitrobenzyl alcohol 
• 39716-58-0 pent-4-enoyl chloride 
• 591-80-0 pent-4-enoic acid 
• 855764-86-2 3-(1,2,3,4-tetrahydro-[2]quinolyl)-propionic acid 
• 93044-04-3 1-(tert-butyl) 6-ethyl 3-oxohexanedioate 
• 81124-50-7 (E)-3-(2-quinolinyl)-2-propenoic acid 
• 6992-97-8 2-(but-3-en-1-yl)aniline 
• 62723-78-8 2-methoxymethylaniline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 1311145-73-9 2-bromo-N-(2-(but-3-enyl)phenyl)acetamide 

Relevant articles and documents

Synthesis of Aryl-Substituted 3,3a,4,5-Tetrahydropyrrolo[1,2- A [ quinolin-1(2 H)-ones and 2,3,4,4a,5,6-Hexahydro-1 H-pyrido[1,2- A [quinolin-1-ones

A new route to the title benzo-fused angular tricyclic amides 3,3a,4,5-tetrahydropyrrolo- A nd 2,3,4,4a,5,6-hexahydro-1 H-pyrido[1,2- A [quinolin-1-ones is reported from 1-(tert-butyl) 6-ethyl 3-oxohexanedioate and 1-(tert-butyl) 7-ethyl 3-oxoheptanedioate. Alkylation of these β-keto diesters with a series of 2-nitrobenzyl bromides followed by acid hydrolysis and decarboxylation gives ethyl 6-(2-nitrophenyl)-4-oxohexanoates and ethyl 7-(2-nitrophenyl)-5-oxoheptanoates, respectively. Reductive amination under hydrogenation conditions followed by ester hydrolysis and condensative ring closure affords the final lactam products. The reactions proceed cleanly and only two chromatographic purifications are required.

Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles

A highly efficient palladium-catalyzed intramolecular aminoalkylation of unactivated alkenes in the absence of an external ligand and oxidant is described. New C-N and C(sp3)-C(sp3) bonds are formed simultaneously. This general transformation allows for construction of diverse N-heterocycles. Mechanistic studies show that the process may involve a four-membered Pd(alkyl)amido intermediate.