66794-10-3Relevant academic research and scientific papers
Method for recycling byproducts in synthesis of diphenyl sulfide compound
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Paragraph 0053-0055; 0058; 0064-0066, (2021/03/30)
The invention provides a method for recycling byproducts in synthesis of a diphenyl sulfide compound. The byproducts comprise alkyl alcohol and dimethyl disulfide. The method comprises the steps of (1) mixing the byproducts in synthesis of the diphenyl sulfide compound with a sodium nitrite aqueous solution, adding concentrated hydrochloric acid for reaction, and obtaining alkyl nitrite and dimethyl disulfide; and (2) mixing the products obtained in the step (1) with copper powder, adding an aniline compound for reaction, carrying out desolvation treatment on the obtained reaction solution toobtain a diphenyl sulfide compound and byproducts, and returning the byproducts to the step (1). According to the recycling method, the byproducts do not need to be separated, the byproducts serve asraw materials to be directly applied to synthesis of the diphenyl sulfide compound, the process steps are simple and safe, cyclic utilization of the materials is achieved, and the raw material cost ofindustrial production of the diphenyl sulfide compound and the treatment cost of industrial three wastes are remarkably reduced.
Method for preparing 2, 3-dimethyl thioanisole
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Paragraph 0036-0073, (2021/04/26)
The invention provides a method for preparing 2, 3-dimethyl thioanisole, and the method comprises the following step of: reacting 2, 3-dimethyl aniline, alkyl nitrite and dimethyl disulfide serving as raw materials under the catalysis of copper powder and
Synthetic method of topramezone intermediate 1,2-dimethyl-3-methylsulfanyl-benzene
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Paragraph 0027-0030, (2019/12/25)
The invention relates to the field of organic synthesis, in particular to a synthetic method of a topramezone intermediate 1,2-dimethyl-3-methylsulfanyl-benzene. The method comprises the following steps: (1) reacting 2,3-dimethylaniline or a salt thereof
Edible essence spice preparation method
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Paragraph 0032-0045, (2019/05/22)
The invention provides an edible essence spice preparation method, wherein the edible essence spice is 2,3-dimethyl benzene methyl sulfide, and the method includes the following steps: taking 3-nitroo-xylene and potassium methyl mercaptan as raw materials
Edible essence spice preparation method
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Paragraph 0041-0054, (2019/05/22)
The invention provides an edible essence spice preparation method, wherein the edible essence spice is 2,3-dimethyl benzene methyl sulfide, and the method includes the following steps: taking a compound of a formula (I) and an alkali metal salt of methyl
Synthesis method and application of topramezone impurity
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Paragraph 0019-0021, (2019/10/01)
The invention discloses a synthesis method of topramezone impurity. The method includes: taking 2, 3-dimethylaniline as the starting raw material, carrying out methyl sulfidation, bromination, oxidation, oximation and chlorination ring-closing to synthesize 3-[3-bromo-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole, and carrying out condensation with 1-methyl-5-hydroxypyrazole under an alkaline condition to synthesize 3-[2-methyl-3-(1-methyl-1H-pyrazole-5-oxyl)-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole. The invention also discloses application of the corresponding product. The synthesis method provided by the invention has the characteristics of simple operation, easily control process, and a product yield of 40%-80%. The obtained product can be used as a standard substancefor detecting and monitoring the synthesis of topramezone.
2. 3 - dimethyl benzoic sulfide preparation method (by machine translation)
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Page/Page column 5-7, (2017/10/07)
The invention discloses a 2, 3 - dimethyl benzoic sulfide preparation method, under inert atmosphere, to 3 - nitro-O-xylene as raw materials, by the nickel salt and cocatalyst effects, in the organic solvent with sodium methyl mercaptan in heating the reaction, the reaction liquid is subjected to post-processing, by 2, 3 - dimethyl benzoic thioether. The preparation process has high yield, low cost, simple and convenient operation, green environmental protection and the like. (by machine translation)
The Synthesis and Crystal Structure of a Novel Pesticide Intermediates
He, Zhipeng,Ren, Tiegang,Li, Yongzhe,Fang, Xiaomin
, p. 419 - 426 (2015/10/12)
A novel pesticide intermediates 3-(6-bromo-2-methyl-3-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole was synthesized with 2,3-dimethylaniline as the starting materials. The final product and intermediates were characterized by mass spectra, 1H NMR, infrared and elemental analysis. The crystal structure of compounds 6 and 8 were determined by single crystal X-ray diffraction. Results shown that two oxazole compounds crystallize in the monoclinic (6) and triclinic (8) with the space group of P 21/c for 6 and P-1 for 8, respectively.
ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
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Paragraph 0509; 0511, (2015/09/23)
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
