223646-24-0Relevant articles and documents
Novel compound, and method for preparing topramezone intermediate from novel compound
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, (2021/05/05)
The invention provides a compound as shown in a general formula A. In the compound, R1 is a halogenated alkyl group, a hydroxyalkyl group, an aldehyde group or a carboxylic acid group; R2 is a methyl groupa; R3 is a cyano group, a chlorine substituted oximido group, or a 4, 5-dihydroisoxazole-3-yl group; and R4 is an alkyl substituted sulfenyl group, an alkyl sulfonyl group or an alkyl sulfoxide group, and the alkyl group is independently selected from methyl, ethyl, propyl and isopropyl. The invention also provides the compound as one or more intermediates for preparing topramezone. In addition, the invention provides a method for preparing a topramezone compound. The topramezone compound is prepared by taking the compound as shown in the general formula A as an intermediate, and the key intermediate of topramezone is finally prepared through chloromethylation or hydroformylation, hydrolysis, hydroxyamination reaction, diazotization halogenation, dipolar cycloaddition and oxidation reaction. The reaction conditions provided by the invention are mild and controllable, the reaction selectivity of each step is good, the yield is relatively high, the generation of some byproducts is avoided, and the product quality is ensured. The whole process route is easy to realize industrialization.
Preparation method of topramezone
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, (2021/01/04)
The invention relates to a preparation method of topramezone. Themethod comprises the following steps of: (1) carrying out oxidation reaction on a compound 5 and an oxidant under the action of a catalyst to obtain a compound 6; (2) carrying out Grignard reaction on the compound 6, magnesium and carbon dioxide to obtain a compound 7; and (3) carrying out condensation reaction on the compound 7 and1-methyl-5-hydroxy pyrazole to obtain topramezone. The structural formula of the compound 5, the structural formula of the compound 6, the structural formula of the compound 7 are described in descriptions of the invention. The preparation method of topramezone has the advantages of few by-products, high purity and yield of topramezone, low wastewater treatment difficulty, low cost, no toxic or side effect in the production process and suitability for industrial production.
Topramezone intermediate and topramezone preparation method
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, (2020/04/06)
The invention relates to the field of organic synthesis, in particular to a topramezone intermediate and a topramezone preparation method. The topramezone preparation method comprises the following steps: 3-[3-halogen-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole and cyanide are subjected to a substitution reaction to obtain 3-[3-cyano-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole; hydrolysis reaction is performed on 3-[3-cyano-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole under the action of acid or alkali to obtain 2-methyl-3-(4, 5-dihydroisoxazole-3-yl)-4-methylsulfonyl benzoic acid; and 2-methyl-3-(4, 5-dihydroisoxazole-3-yl)-4-methylsulfonyl benzoic acid and 1-methyl-5-hydroxypyrazole are condensed and rearranged to generate topramezone. According to the topramezone intermediate and the topramezone preparation method provided by the invention, the use of an expensive palladium catalyst and a dangerous butyl lithium reagent is avoided, the yield isrelatively high, the cost is reduced, the process is simplified, the defects in the prior art are overcome, and the industrial value is achieved.
Preparation method of 3-substituted phenyl-4,5-dihydroisoxazole derivative and application and intermediate thereof
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, (2019/10/01)
The invention relates to a preparation method of a 3-substituted phenyl-4,5-dihydroisoxazole derivative and application and an intermediate thereof. A cyano compound (V) is converted into an N-hydroxybenzimidium compound (VII), and then 3-substituted phenyl-4,5-dihydroisoxazole intermediate (IX) is synthesized through a diazotization chlorination reaction and a dipolar cycloaddition reaction; a reaction condition is mild and controllable, the reaction selectivity in each step is good, the yield is relatively high, production of some byproducts is avoided, the product quality is guaranteed, andindustrialization of a whole technological route is easy to implement.
Improved method for preparing topramezone
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, (2018/07/30)
The invention discloses an improved method for preparing topramezone and belongs to the technical field of chemical synthesis. The improved method takes 3-nitro-o-xylene as a raw material and is characterized in that the topramezone is obtained through oximation reaction, ethylene cyclization, palladium carbon reduction, diazotization, aldehydelation, oxidation and condensation rearrangement reaction; under optimal conditions, the total yield is 33.7 percent, the raw material is cheap and easy to obtain, the treatment is convenient in the whole process, the yield is relatively high, and a certain significance in industrialized production is realized.
Novel benzoylpyrazole compounds, intermediate preparing therefor and herbicides
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, (2008/06/13)
PCT No. PCT/JP98/04898 Sec. 371 Date Dec. 8, 1998 Sec. 102(e) Date Dec. 8, 1998 PCT Filed Oct. 29, 1998 PCT Pub. No. WO99/23094 PCT Pub. Date May 14, 1999A compound represented by the general formula [I](wherein R1 is a C1-C6 alkyl group; R2 is a C1-C6 alkylsulfonyl group and the like; R3 and R4 are each independently hydrogen or a C1-C6 alkyl group; R5 is hydrogen or a benzyl group or the like; R7, R8, R9 and R10 are each independently hydrogen or a C1-C6 alkyl group.) or a herbicide containing a salt thereof, intermediate preparing therefor, and the said compound.
