66849-29-4

Basic information

• Product Name: (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE
• Synonyms: (S)-2-(1-PHENYLETHYLAMINO)ETHANOL;(S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE;(S)-(-)-N-(2-HYDROXYETHYL)-PHENYLETHYLAMINE;(S)-(+)-N-(2-HYDROXYETHYL)-PHENYLETHYLAMINE;(s)-(-)-n-(2-hydroxyethyl)-alpha-methylbenzylamine;(S)-(-)-N-(2-Hydroxyethyl)-alpha-phenylethylamine,99%;2-[[(1S)-1-Phenylethyl]amino]ethanol
• CAS NO: 66849-29-4
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.23
• Mol File: 66849-29-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 76°C
• Boiling Point: 293.09°C (rough estimate)
• Flash Point: 114.4 °C
• Appearance: Clear colorless/Liquid
• Density: 1.0203 (rough estimate)
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.532-1.535
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(66849-29-4)
• EPA Substance Registry System: (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(66849-29-4)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-36-25
• Safety Statements: 37/39-26-45
• Hazardous Substances Data: 66849-29-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C10H15NO/c1-9(11-7-8-12)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3/p+1/t9-/m0/s1

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 540-51-2 2-bromoethanol 
• 2627-86-3 (-)-α-methylbenzylamine 
• 107-07-3 2-chloro-ethanol 
• 75-21-8 oxirane 
• 164219-32-3 (S)-2-oxo-2-((1-phenylethyl)amino)acetic acid 
• 164219-31-2 ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate 

Downstream Products

• 817168-33-5 4-((S)-1-Phenyl-ethyl)-morpholine-2,3-dione 
• 1357081-31-2 C₁₂H₁₅NO₂ 
• 1340543-83-0 (-)-(6R,7R)-6-hydroxy-7-phenyl-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-04-8 (-)-(6S,7S)-6-hydroxy-7-phenyl-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-05-9 (-)-(6S,7S)-6-hydroxy-7-(2-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340543-84-1 (-)-(6R,7R)-6-hydroxy-7-(2-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-06-0 (-)-(6S,7S)-6-hydroxy-7-(3-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340543-85-2 (-)-(6R,7R)-6-hydroxy-7-(3-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340543-86-3 (-)-(6R,7R)-6-hydroxy-7-(4-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-07-1 (-)-(6S,7S)-6-hydroxy-7-(4-nitrophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-08-2 (-)-(6S,7S)-6-hydroxy-7-(2,6-dichlorophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340543-87-4 (-)-(6R,7R)-6-hydroxy-7-(2,6-dichlorophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 
• 1340544-09-3 (-)-(6S,7S)-6-hydroxy-7-(3,4-dichlorophenyl)-4-[(S)-1-phenylethyl]-1,4-oxazepan-5-one 

Relevant articles and documents

Chemodivergent synthesis of 7-aryl/alkyl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl/alkyl(hydroxy)methyl]morpholin-3-ones from a common epoxyamide precursor

We present here a regiospecific synthesis of 7-alkyl- or 7-aryl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl(hydroxy)methyl]- or 2-(1-hydroxyalkyl)morpholin-3-ones from a diastereomeric mixture of trans-3-alkyl- or -3-aryl-N-(2-hydroxyethyl)-N-(1-phenylethyl)oxirane-2- carboxamides. This chemodivergent synthesis is easily controlled by an appropriate choice of cyclization reaction conditions. Georg Thieme Verlag Stuttgart - New York.

Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: Intermediates in the synthesis of aprepitant

The preparation of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones from N-substituted β-amino alcohols is reported. These were useful intermediates in the synthesis and development of aprepitant.

Process for preparation of pyrimidine derivatives

The present invention relates to a process for preparation of 5,6-dimethyl-2-(4-fluorophenyl-amino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine represented by the following formula (I), STR1 and its acid addition salts by reacting a pyrimidi