66859-48-1

Usage

Uses

Used in Pharmaceutical Industry:
4-amino-2-phenylbutanoic acid (HCl) is used as an intermediate in the synthesis of pharmaceutical drugs, particularly for the production of analgesics and anxiolytics. It plays a crucial role in the development of medications for pain management and the treatment of neurological disorders such as epilepsy and anxiety.
Used in Medicinal Chemistry:
4-amino-2-phenylbutanoic acid (HCl) serves as a valuable building block in medicinal chemistry for the design and synthesis of novel therapeutic agents targeting various diseases and conditions. Its unique structure allows for the exploration of new drug candidates with potential applications in different areas of medicine.

Upstream product

• 132769-61-0 3-phenyl-pent-4-ene nitrile 
• 918149-83-4 (S)-(+)-N-(3-phenyl-pent-4-enyl)-benzamide 
• 918149-64-1 (S)-(-)-3-phenyl-4-pentenamide 
• 918149-84-5 (R)-(-)-4-benzoylamino-2-phenyl-butyric acid 
• 83-13-6 diethyl 2-phenylmalonate 
• 92647-37-5 diethyl (2-cyanomethyl)-2-phenylpropanedioate 
• 67465-34-3 2-(2-Amino-ethyl)-2-phenyl-malonic acid diethyl ester; hydrochloride 

Relevant academic research and scientific papers

An unusual β-vinyl effect leading to high efficiency and enantioselectivity of the amidase, nitrile biotransformations for the preparation of enantiopure 3-arylpent-4-enoic acids and amides and their applications in synthesis

(Chemical Equation Presented) Biotransformations of 3-arylpent-4- enenitriles catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase/amidase-containing microbial whole-cell catalyst were studied, and an unusual β-vinyl effect of the substrate on

Potential GABAB Receptor Antagonists. X* the Synthesis of Further Analogues of Baclofen, Phaclbfen and Saclofen

In an attempt to obtain new compounds with binding activity at the GABAB receptor site, we report the synthesis of 3-amino-2-arylpropanoic acids, and the sulfonic, phosphonic and hydroxamic acid analogues. In addition, we report the synthesis of the isomer of phaclofen, 3-amino-1-(4-chlorophenyl)-propylphosphonic acid, and the higher homologue of baclofen, 5-amino-2-(4-chlorophenyl)pentanoic acid.