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Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and potential pharmacological properties make it a valuable compound for the development of new drugs.
Used in Organic Synthesis:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a key building block in the synthesis of complex organic molecules. Its reactivity and functional groups allow for various chemical reactions, making it a versatile compound in organic chemistry.
Used in Drug Discovery Research:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a research tool in drug discovery. Its potential pharmacological properties and unique structure make it an interesting candidate for the development of new therapeutic agents. Researchers in the field of drug discovery use 5-CHLORO-2-P-TOLYL-1H-INDOLE to study its interactions with biological targets and evaluate its potential as a lead compound for further development.

Upstream product

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Relevant academic research and scientific papers

Regioselective Synthesis of 2-Arylindoles via Palladium-Catalyzed Cyclization of Phenylglyoxal and 2-Anilinoacetophenones with Anilines

A versatile route has been developed for the synthesis of 2-arylindoles using a Pd-catalyzed tandem process. Under reductive conditions, different 2-arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2-anilinoacetophenones intermediates also can be using to give access to the corresponding 2-arylindoles.

Stereoselective synthesis of 3-spiropiperidino indolenines via SN2-type ring opening of activated aziridines with 1H-indoles/Pd-catalyzed spirocyclization with propargyl carbonates

3-Spiropiperidino indolenines have been synthesized via novel Lewis acid-catalyzed SN2-type ring opening of activated aziridines with 1H-indoles followed by Pd-catalyzed dearomative spirocyclization with propargyl carbonates in up to 88% yields

Design and applications of new phosphine-free tetradentate Pd-catalyst: Regioselective C–H activation on 1-substituted 1,2,3-triazoles and indoles(NH-Free)

This article describes the synthesis of a new phosphine free tetradentate Pd catalyst using dl-2,3-diaminopropionic acid. The complex was characterized by Mass, IR, and 1H NMR. The catalyst is air stable at room temperature and non-hygroscopic. Application of this new catalyst to regioselective C–H activation on 1-substituted 1,2,3-triazole and indoles with aryl iodides to get corresponding C-5 and C-2 arylated products with satisfactory yields. All the products were characterized by spectroscopic studies.

Cycloisomerization of 2-alkynylanilines to indoles catalyzed by carbon-supported gold nanoparticles and subsequent homocoupling to 3,3′-biindoles

Elevated by the support: 2-Alkynyl aniline cycloisomerization to indole is catalyzed by cationic Au NPs on a carbon support. Electroneutral and rich 2-aryl indoles are further converted into 3,3′-biindoles by oxidative homocoupling that is readily catalyzed by the Au NPs on carbon, and exclusively but also somewhat sluggishly by the carbon support. Copyright

Indium-HI-mediated one-pot reaction of 1-(2-arylethynyl)-2-nitroarenes to 2-arylindoles

While 1-(2-arylethynyl)-2-nitroarenes were reduced to 2-(2-arylethynyl)anilines in the presence of indium and InCl3 in THF/H2O (v/v = 5/1) at 50 °C, 1-(2-arylethynyl)-2-nitroarenes were reductively cyclized to 2-arylindoles with good yields in the presence of indium and aqueous HI in benzene.