66883-92-9

Usage

Uses

Used in Materials Science:
[4-(morpholin-4-yl)benzylidene]propanedinitrile is used as a building block for the synthesis of new organic compounds in the field of materials science. Its unique chemical structure and reactivity contribute to the development of novel materials with a range of properties.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [4-(morpholin-4-yl)benzylidene]propanedinitrile is used as a key component in the synthesis of various organic compounds. Its potential applications in this field are currently being explored, with a focus on leveraging its unique properties to create new molecules for drug development and therapeutic applications.

Upstream product

• 110-91-8 morpholine 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 2826-22-4 4-fluorobenzylidenemalononitrile 

Downstream Products

• 812666-84-5 5-amino-3-oxo-2-[4-(morpholin-4-yl)benzylidenyl]-7-[4-(morpholin-4-yl)phenyl]-2,3-dihydro-7H-thiazolo[3,2-a]pyridin-6,8-dicarbonitrile 
• 1174730-38-1 7-amino-6-cyano-5-[4-(4-morpholinyl)phenyl]-2-thioxopyrido[2,3-d]pyrimidin-4(1H)-one 
• 1369588-78-2 5-amino-1-benzyl-6,8-dicyano-7-[4-(4-morpholinyl)phenyl]-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate 
• 1369588-80-6 5-amino-6,8-dicyano-7-[4-(4-morpholinyl)phenyl]-1-(prop-2-en-1-yl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate 
• 1369588-75-9 5-amino-6,8-dicyano-1-methyl-7-[4-(4-morpholinyl)phenyl]-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate 

Relevant academic research and scientific papers

Ultrasound-assisted and efficient knoevenagel condensation reaction catalyzed by silica sodium carbonate nanoparticles

An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano- or ethylciano acetates in a one-pot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described. In this reaction, SSC NPs demonstrated high efficiency as catalyst to obtain target products. By this achievement, a wide range of α,β-unsaturated compounds as Knoevenagel condensation products with good to excellent yields are obtained from reaction between numerous arylaldehydes, and malononitrile, methyl cianoacetate or ethyl cianoacetate. Target products which prepared in high yield and high purity can be candidate as important biologically active molecules. This method is an easy, cheap, rapid and highly efficient for the synthesis of desired products. In addition, capability of catalyst to separate from reaction mixture and reuse in further runs and being compatible with green chemistry are considered as other advantages of this procedure. All products were deduced from their FT-IR and FT-NMR spectroscopic and elemental analysis data.

Syntheses of hitherto unknown thiazole, ylidene and pyridinethione derivatives having a piperidin-1-yl moiety and their use as antimicrobial agents

The novel hydrazone derivatives 2a-c were prepared by treatment of aldehydes 1a,b with some hydrazines. Thiocarbamoyl functional group in compound 2a was subjected to cyclization reactions with some α-halocarbonyl reagents and furnished the novel thiazoles 4-6, 8 and 9. Enaminonitrile 10 and pyridinone 13 derivatives were synthesized by interaction of active methylene compound 2b with N,N-dimethylformamide-dimethylacetal and ketene dithioacetal 11, respectively. Aliphatic, aromatic and heteroaromatic active methylene compounds were condensed with aldehydes 1a,b to afford the new ylidenes 15a-d, 19a,b, 20 and 21. Substituted pyridinethiones 22 and 23 were prepared in high yields by cyclocondensation of 15c with malononitrile and ethyl cyanoacetate, respectively. Indeno[1,2-b]pyridines 26a,b were obtained by the reaction of ylidenes 19a,b with cyanothioacetamide in ethanol and in the presence of sodium ethoxide under reflux. The structures of the synthesized compounds were established from their analytical and spectral data. The prepared compounds were also screened for their antimicrobial activity.

New pyridinecarbonitriles from fluoro arylpropenones

The facile synthetic approaches to 3-pyridinecarbonitriles are described.The first approach involves the base-catalyzed transformation of 4-hydroxy-1,1-cyclohexanedicarbonitrile 2a into 4a, b.The other route involves the base-catalyzed multi-step one-pot reaction of aryl methyl ketones with the appropriate arylidenemalononitriles 6, 11a, b.Careful study of the synthesis of 2a, b from 1a, b revealed the importance of controlling the reaction conditions.Thus, 1,7-dioxo-4,4-heptanedicarbonitriles 3a, b or 3-pyridinecarbonitrile 4a were obtained in addition to the desired 2a, b under different basic conditions.

Tyrphostins I: Synthesis and Biological Activity of Protein Tyrosine Kinase Inhibitors

A novel class of low molecular weight proteine kinase inhibitors is described.These compounds consitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain.These competitive inhibitors also effectively block the EGF-dependent autophosphorylation of the receptor.The potent EGF receptor kinase blockers examined were found to competitively inhibit the homologous insulin receptor kinase at 102-103 higher inhibitor concentrations in spite of the significant homology between these protein tyrosine kinases.These results demonstrate the ability to synthesize selective tyrosine kinase inhibitors.The most potent EGF receptor kinase inhibitors also inhibit the EGF-dependent proliferation of A431/clone 15 cells with little or no effect on EGF independent cell growth.These results demonstrate the potential use of protein tyrosine kinase inhibitors as selective antiproliferative agents for proliferative diseases caused by the hyperactivity of protein tyrosine kinases.We have suggested the name "tyrphostins" for this class of antiproliferative compounds which act as protein tyrosine kinase blockers.

Catalyst compositions for trimerizing organic isocyanates

Disclosed are novel compositions capable of catalytically trimerizing organic isocyanates said compositions comprising solutions of the reaction products obtained by reacting in an inert solvent in substantially equimolar proportions electron-rich ketene-aminals with electron-poor olefins having the respective formulae (I) and (II) STR1 The variously substituted electron-rich ketene-aminals (I), as the name implies, have high electron density associated with the double bond because of the two tertiary amine groups while the electron-poor olefins (II) have the opposite situation due to the presence of electron withdrawing substituents R9 and R10. Also disclosed is an improved process for trimerizing organic isocyanates using the above catalyst compositions including the preparation of polyisocyanurate polymers and isocyanurate-modified polyisocyanates.