66892-35-1

Upstream product

• 590-92-1 3-Bromopropionic acid 
• 5858-17-3 3,4-dichlorothiophenol 

Downstream Products

• 1421435-08-6 2-[2-(6,7-dichlorothiochroman-4-ylidene)hydrazinyl]-5-phenylthiazole 
• 1354964-73-0 (Z)-2-(2-(7,8-dichloro-4H-thiachromeno[4,3-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 1354964-72-9 (E)-2-(2-(7,8-dichloro-4H-thiachromeno[4,3-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 1612925-27-5 C₁₉H₁₂Cl₂N₄O₅S₂ 
• 1612925-41-3 C₁₉H₁₂Cl₂N₄O₅S₂ 
• 1612925-30-0 C₁₉H₁₂Cl₂N₄O₆S₂ 
• 1612925-44-6 C₁₉H₁₂Cl₂N₄O₆S₂ 
• 1315306-65-0 6',7'-dichloro-3-(4-chlorophenyl)spiro[oxirane-2,3'-thiochroman]-4'-one 

Relevant academic research and scientific papers

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction

The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro ch

Hydantoin derivatives as therapeutic agents

A series of spiro-hydantoin compounds has been prepared by condensing the appropriate carbonyl ring compound, such as the corresponding 1-indanone, 1-tetralone, 4-chromanone, thiochroman-4-one, 7,8-dihydroquinolin-5(6H)-one, 6,7-dihydropyrindin-5(5H)-one, thiondane-3-one-1,1-dioxide and 4-oxoisothiochroman-2,2-dioxide, respectively, with potassium cyanide and ammonium carbonate. The resulting hydantoin derivatives are found to be useful in preventing or alleviating chronic diabetic complications. Preferred member compounds include spiro-[imidazolidine-4,1'-indan]-2,5-dione, 6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6-chloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,7-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,8-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6'-fluoro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione and 6',7'-dichloro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione.