668970-91-0

Usage

Uses

Used in Organic Synthesis:
4-Ethynyl-3,5-dimethyl-isoxazole is used as a building block in organic synthesis for creating more complex molecules. Its unique structure allows for the development of a wide range of chemical compounds with diverse properties and applications.
Used in Pharmaceutical Industry:
4-Ethynyl-3,5-dimethyl-isoxazole is used as a starting material in the development of new drugs. Its antimicrobial properties and potential applications in the pharmaceutical industry make it a valuable compound for research and drug discovery.
Used in Agricultural Industry:
4-Ethynyl-3,5-dimethyl-isoxazole is also used in the agricultural industry, where it can be employed in the development of new agrochemicals. Its antimicrobial properties may contribute to the creation of effective pesticides or other agricultural products.
Used in Research:
4-Ethynyl-3,5-dimethyl-isoxazole is utilized in research settings to study its chemical properties and potential applications. Its unique structure and reactivity make it an interesting subject for scientific investigation and the development of new methodologies in organic chemistry.

Upstream product

• 1201657-82-0 3,5-dimethyl-4-((trimethylsilyl)ethynyl)isoxazole 
• 10557-85-4 4-iodo-3,5-dimethylisoxazole 
• 300-87-8 3,5-dimethyl-1,2-oxazole 

Downstream Products

• 1400887-82-2 C₂₅H₂₅F₃N₂O₄S 
• 1443684-92-1 4-bromo-2-((3,5-dimethylisoxazol-4-yl)ethynyl)aniline 

Relevant academic research and scientific papers

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors

A fragment library of electrophilic small heterocycles was characterized through cysteine-reactivity and aqueous stability tests that suggested their potential as covalent warheads. The analysis of theoretical and experimental descriptors revealed correlations between the electronic properties of the heterocyclic cores and their reactivity against GSH that are helpful in identifying suitable fragments for cysteines with specific nucleophilicity. The most important advantage of these fragments is that they show only minimal structural differences from non-electrophilic counterparts. Therefore, they could be used effectively in the design of targeted covalent inhibitors with minimal influence on key non-covalent interactions.

GOLD (I)-PHOSPHINE 1,2,3-TRIAZOLE DERIVATIVES WITH ANTIOBIOTIC PROPERTIES

The present invention relates to gold (l)-phosphine 1,2,3-triazole compounds, and their use in a human or animal medicine. The present invention also relates to using such compounds for the prevention and/or treatment of an infection, i.e. inhibitors of growth of Gram-positive and/or Gram-negative bacteria. On another aspect the invention relates to the synthesis of the gold (l)-phosphine compounds of the invention and to their synthesis intermediates. The present invention finds applications in the medical, veterinary and/or chemical fields.

Structure-based design of orally bioavailable 1 h -Pyrrolo[3,2- C ]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)

The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-defic

7-AZAINDOLE INHIBITORS OF CRAC

Disclosed are compounds of Formula (I), useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.