668988-19-0Relevant articles and documents
A versatile synthesis of α-amino acid derivatives via the ugi four-component condensation with a novel convertible isonitrile
Rikimaru, Kentaro,Yanagisawa, Barata,Kan, Toshiyuki,Fukuyama, Tohru
experimental part, p. 403 - 417 (2009/09/08)
The Ugi four-component condensation (4CC) reaction with the carbonate-type isonitrile 9 proceeded smoothly, and subsequent base treatment of the Ugi products 10 provided the N-acyloxazolidinones 11 in high yield. The N-acyloxazolidinone derivatives can be reacted with several hetero-nucleophiles, namely, reaction of 11 with thiolates gave thiol ester derivatives 16 efficiently.