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669-78-3

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669-78-3 Usage

Description

Difluoromaleic anhydride, with the molecular formula C4H2F2O3, is a chemical compound that is highly reactive and widely used in organic chemistry for the synthesis of various other compounds. It is a strong electrophile, capable of undergoing reactions with a range of nucleophiles to form diverse chemical products. Its unique ability to introduce fluorine atoms into organic molecules and react with dienes makes it a valuable building block in the fields of polymer chemistry, materials science, pharmaceuticals, and agrochemicals.

Uses

Used in Organic Chemistry:
Difluoromaleic anhydride is used as a reagent for the synthesis of various organic compounds due to its strong electrophilic nature and ability to react with a variety of nucleophiles.
Used in Pharmaceutical Production:
Difluoromaleic anhydride is used as a key intermediate in the production of pharmaceuticals, leveraging its versatile reactivity to introduce fluorine atoms into organic molecules, which can enhance the properties and efficacy of the resulting drugs.
Used in Agrochemicals:
In the agrochemical industry, difluoromaleic anhydride is used as a building block for the synthesis of various agrochemicals, contributing to the development of more effective and environmentally friendly products.
Used in Polymer Chemistry:
Difluoromaleic anhydride is used as a monomer in polymer chemistry, taking advantage of its unique ability to react with dienes to create novel polymeric materials with specific properties.
Used in Materials Science:
In materials science, difluoromaleic anhydride is utilized in the development of new materials with tailored properties, such as improved thermal stability, chemical resistance, or specific optical characteristics, by incorporating fluorine atoms into their molecular structure.

Check Digit Verification of cas no

The CAS Registry Mumber 669-78-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,6 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 669-78:
(5*6)+(4*6)+(3*9)+(2*7)+(1*8)=103
103 % 10 = 3
So 669-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C4F2O3/c5-1-2(6)4(8)9-3(1)7

669-78-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-difluorofuran-2,5-dione

1.2 Other means of identification

Product number -
Other names Difluoromaleic anhydride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:669-78-3 SDS

669-78-3Relevant articles and documents

Hydrogen-bond symmetry in difluoromaleate monoanion

Perrin, Charles L.,Karri, Phaneendrasai,Moore, Curtis,Rheingold, Arnold L.

supporting information; experimental part, p. 7766 - 7772 (2012/07/02)

The symmetry of the hydrogen bond in hydrogen difluoromaleate monoanion is probed by X-ray crystallography and by the NMR method of isotopic perturbation in water, in two aprotic organic solvents, and in an isotropic liquid crystal. The X-ray crystal structure of potassium hydrogen difluoromaleate shows a remarkably short O-O distance of 2.41 A and equal O-H distances of 1.206 A, consistent with a strong and symmetric hydrogen bond. Incorporation of 18O into one carboxyl group allows investigation of the symmetry of the H-bond in solution by the method of isotopic perturbation. The 19F NMR spectra of the mono-18O-substituted monoanion in water, CD2Cl2, and CD3CN show an AB spin system, corresponding to fluorines in different environments. The difference is attributed to the perturbation of the acidity of a carboxylic acid by 18O, not to the mere presence of the 18O, because the mono-18O dianion shows equivalent fluorines. Therefore, it is concluded that the monoanion exists as an equilibrating pair of interconverting tautomers and not as a single symmetric structure not only in water but also in organic solvents. However, in the isotropic liquid crystal phase of 4-cyanophenyl 4-heptylbenzoate, tetrabutylammonium hydrogen difluoromaleate- 18O shows equivalent fluorines, consistent with a single symmetric structure. These results support earlier studies, which suggested that the symmetry of hydrogen bonds can be determined by the local environment.

PROCESS FOR THE PREPARATION OF DIFLUOROMALEIC ANHYDRIDE AND INTERMEDIATE COMPOUNDS PRODUCED THEREBY

-

, (2008/06/13)

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AN ABBREVIATED ROUTE TO DIFLUOROMALEIC ANHYDRIDE

Krespan, Carl G.

, p. 339 - 343 (2007/10/02)

Difluoromaleic anhydride is obtained in good yield by reaction of either hexafluoro-2,5-dihydrofuran or hexafluoro-2,5-dihydrothiophene with sulfur trioxide.Hexafluoro-2,5-dihydrothioyphene is prepared from sulfur and commercially available hexafluorocyclobutene, so its conversion to difluoromaleic anhydride in one step makes the latter readily available as well.

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