66902-63-4Relevant academic research and scientific papers
Chemical synthesis of some novel 6-aminouracil-2-thiones and their glycoside analogues
Gaafar,Aly,Abu-Zied, Khadiga M.,Abdel-Rahman, Asmaa E.,Helmy
, p. 779 - 797 (2017/04/17)
6-AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4a-j. The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7a-d. The C-glycosides 8a, b and 9c-e were successfully prepared through condensing compound 1 and the appropriate sugar in the presence of chloroacetic acid. The behavior of certain S-alkyl derivative 4 towards amines and hydrazines was also studied. Structure elucidations for the new products were supported by compatible chemical and spectral measurements.
Formation of Mesoionic Thiazolopyrimidines from 2-Thiouracil Derivatives
Talukdar, P. B.,Sengupta, S. K.,Datta, A. K.
, p. 275 - 278 (2007/10/02)
Carboxymethylthio derivatives (III, R2= H, Ph) from some 2-thiouracil derivatives (I) show considerable variation in their solubility behaviour in water and stability towards various reagents.Cyclodehydration of III (R2 = Ph) and VII
