669056-40-0

Upstream product

• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 
• 53-16-7 Estrone 
• 50-01-1 guanidine hydrochloride 
• 669056-39-7 3-benzyloxy-16-(N-methyl-N-phenylaminomethylidene)-estra-1,3,5⁽¹⁰⁾-triene-17-one 

Downstream Products

• 1199558-96-7 3-benzyloxyestra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(O-benzyl-N-tert-butoxycarbonyl-L-serinylamino)pyrimidine 
• 1199558-94-5 3-benzyloxyestra-1,3,5(10),16-tetraeno[17,16-e]-2'-(N-tert-butoxycarbonyl-L-α-aminobutyrylamino)pyrimidine 
• 1199558-95-6 3-benzyloxyestra-1,3,5(10),16-tetraeno[17,16-e]-2'-(N-tert-butoxycarbonyl-L-α-alaninylamino)pyrimidine 
• 669056-34-2 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(S-benzyl-N-tert-butoxycarbonyl-L-cysteinylamino)pyrimidine 

Relevant academic research and scientific papers

Estrano[17,16-e]pyrimidine-peptide conjugates

The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.

Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidinepeptide conjugates

Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radio label for the potential detection of estrogen positive breast cancer cells.