669066-90-4

Usage

Uses

Used in Antiviral Applications:
5-Bromo-3-fluoropicolinaMide is used as a building block for the synthesis of Favipiravir, an antiviral agent. Favipiravir is particularly effective in the treatment of advanced Ebola virus infection in small animal models. It has been shown to suppress the replication of Zaire Ebola virus and prevent lethal outcomes in 100% of the animals treated. Based on these studies, Favipiravir, and by extension, 5-Bromo-3-fluoropicolinaMide, can be considered a promising candidate for the treatment of Ebola hemorrhagic fever.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-3-fluoropicolinaMide is used as a key intermediate in the development of new antiviral drugs. Its unique structural features make it a valuable component in the design and synthesis of novel therapeutic agents targeting various viral infections. 5-broMo-3-fluoropicolinaMide's role in the synthesis of Favipiravir highlights its potential for further research and development in the fight against viral diseases.

InChI:InChI=1S/C6H4BrFN2O/c7-3-1-4(8)5(6(9)11)10-2-3/h1-2H,(H2,9,11)

Upstream product

• 669066-89-1 3-amino-5-bromopyridine-2-carboxylic acid amide 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 

Downstream Products

• 669066-91-5 5-bromo-3-fluoro-pyridine-2-carboxylic acid 
• 886373-28-0 5-bromo-3-fluoropyridine-2-carbonitrile 
• 943975-67-5 C₁₅H₁₃Cl₂FN₆ 
• 943975-52-8 C₁₉H₂₁Cl₂FN₆OS 
• 943975-66-4 C₁₆H₁₅Cl₂FN₂O₂ 
• 943975-51-7 C₂₀H₂₃Cl₂FN₂O₃S 
• 943975-65-3 C₁₆H₁₆ClFN₂O₂ 
• 943975-50-6 C₂₀H₂₄ClFN₂O₃S 
• 761400-02-6 C₁₅H₁₃Cl₂FN₂O₂ 
• 943975-49-3 C₁₉H₂₁Cl₂FN₂O₃S 
• 943975-64-2 C₁₅H₁₄ClFN₂O₂ 
• 943975-48-2 C₁₉H₂₂ClFN₂O₃S 
• 669066-93-7 5-bromo-3-fluoropyridine-2-carboxaldehyde 

Relevant academic research and scientific papers

Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series

SAR study of the biphenyl region of cyclopropanecarboxamide derived bradykinin B1 antagonists was examined. Incorporation of a pyridine in place of the proximal phenyl ring and chlorination of the distal phenyl ring proved to be well tolerated

INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS

Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.

ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS

α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3)(CH2)nNRbSO2Rd.(4)(CH2)nNRbCO2Ra.(5)(CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or(b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6)(CH2)kCO2Ra.and (7)(CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3-to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl;

AMINO CYCLOPROPANE CARBOXAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS

Compounds disclosed herein are bradykinin Bl antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.