15862-37-0

Basic information

• Product Name: 2,5-Dibromo-3-nitropyridine
• Synonyms: 2,5-Dibromo-3-nitropyridine;Nsc170627;2,5-Dibromo-3-nitropyridine ,97%;2,5-Dibromo-3-nitropyridi...;Pyridine,2,5-dibroMo-3-nitro-;2,5-DibroMo-3-nitro-pyridine
• CAS NO: 15862-37-0
• Molecular Formula: C₅H₂Br₂N₂O₂
• Molecular Weight: 281.89
• EINECS: -0
• Product Categories: Pyridine series;Pyridine;Heterocyclic Compounds;Pyridines;Thiazines ,Thiazoles
• Mol File: 15862-37-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 92.0 to 96.0 °C
• Boiling Point: 272.7 °C at 760 mmHg
• Flash Point: 118.7 °C
• Appearance: Yellow/Solid
• Density: 2.221 g/cm³
• Vapor Pressure: 0.00263mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: soluble in Methanol
• PKA: -5.60±0.20(Predicted)
• CAS DataBase Reference: 2,5-Dibromo-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dibromo-3-nitropyridine(15862-37-0)
• EPA Substance Registry System: 2,5-Dibromo-3-nitropyridine(15862-37-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 15862-37-0(Hazardous Substances Data)

Usage

Uses

2,5-Dibromo-3-nitropyridine is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Preparation

synthesis of 2,5-Dibromo-3-nitropyridine: To a suspension 5-bromo-3-nitro-pyridin-2-ol (20 g, 91.32 mmol) in toluene (100 ml) was added DMF (0.7 ml, 9.13 mmol) and the mixture was heated to 90°C. (the reaction mixture was protected from light). A solution of POBr3 (31. 41 g, 109.51 mmol) in toluene (40 ml) was added dropwise at 90°C. and the reaction mixture was stirred at that temperature for 16 h. The mixture was allowed to cool to room temperature and toluene (50 ml) and water (50 ml) were added. The organic layer was separated, washed successively with aqueous 1N NaOH (60 ml), water (60 ml) and brine (30 ml), dried with Na2SO4 and evaporated obtain 2,5-Dibromo-3-nitropyridine. Yellow solid, yield 25.2 g, 97%.

InChI:InChI=1/C5H2Br2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H

Upstream product

• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 15862-34-7 5-bromo-3-nitro-1H-pyridin-2-one 
• 7789-59-5 phosphorus(V) oxybromide 
• 6332-56-5 2-hydroxy-3-nitropyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 6945-68-2 5-bromo-3-nitro-pyridin-2-ylamine 

Downstream Products

• 588729-99-1 3-amino-5-bromo-2-chloropyridine 
• 90902-84-4 2,5-dibromopyridin-3-ylamine 
• 638205-26-2 5-bromo-3-nitro-2-phenylethynyl-pyridine 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 1259440-34-0 5-bromo-2-(4-methoxyphenyl)-3-nitropyridine 
• 1259440-38-4 5-bromo-2-(3-methoxyphenyl)-3-nitropyridine 
• 1259441-33-2 2-(2-methoxyphenyl)-3-nitropyridine 
• 1259441-35-4 2,5-bis(2-methoxyphenyl)-3-nitropyridine 

Relevant articles and documents

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The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

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