669068-16-0

Basic information

• Product Name: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine
• Synonyms: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine;tert-Butyl 4-(aminomethyl)-4-(4-chlorophenyl)piperidine-1-carboxylate
• CAS NO: 669068-16-0
• Molecular Formula: C₁₇H₂₅ClN₂O₂
• Molecular Weight: 324.8456
• Mol File: 669068-16-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine(669068-16-0)
• EPA Substance Registry System: 1-Boc-4-(4-chlorophenyl)4-piperidinemethanamine(669068-16-0)

Safety Data

• Hazardous Substances Data: 669068-16-0(Hazardous Substances Data)

Usage

Purpose

Medication to block the effects of opioids in the digestive system

Mechanism of Action

Selective, peripherally acting mu-opioid receptor antagonist

Target

Opioid receptors in the gastrointestinal tract

Function

Reduces the risk of constipation and other gastrointestinal side effects associated with opioid use

Administration

Typically administered in a hospital setting

Indications

Management of postoperative ileus

Additional Benefits

Helps manage opioid-induced bowel dysfunction and prevent complications in patients undergoing surgery or taking opioids for pain management.

Upstream product

• 218451-34-4 4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1092790-63-0 C₂₇H₂₃ClN₄O₂ 
• 885500-71-0 2-[4-(4-chlorophenyl)-piperidin-4-ylmethyl]-isoindole-1,3-dione 
• 885500-57-2 4-[4-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydroisoindol-2-ylmethyl)-piperidin-1-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 885500-56-1 4-[4-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydroisoindol-2-ylmethyl)-piperidin-1-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid ethyl ester 
• 887129-10-4 4-(4-chloro-phenyl)-4-{[3-(2,4-dimethoxy-benzyl)-4-oxo-3,4-dihydro-quinazolin-7-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 885653-41-8 C-(4-(4-chlorophenyl)piperidin-4-yl)methylamine 

Relevant articles and documents

Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration

Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in the potency and selectivity of the compounds, resulting in the identification of nanomolar 6-(piperidin-1-yl)purine, 4-(piperidin-1-yl)-7-azaindole, and 4-(piperidin-1-yl)pyrrolo[2,3-d]pyrimidine inhibitors of PKBβ with antiproliferative activity and showing pathway inhibition in cells. A divergence in the binding mode was seen between 4-aminomethylpiperidine and 4-aminopiperidine containing molecules. Selectivity for PKB vs PKA was observed with 4-aminopiperidine derivatives, and the most PKB-selective inhibitor (30-fold) showed significantly different bound conformations between PKA and PKA-PKB chimera.

ORTHO-CONDENSED PYRIDINE AND PYRIMIDINE DERIVATIVES (E.G. PURINES) AS PROTEIN KINASES INHIBITORS

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NAPHTHAMIDE DERIVATIVES AND THEIR USE

Compounds having the following structure wherein R1, R2, R3, R4, m and n are as defined in the specification, in vivo-hydrolysable precursors thereof, pharmaceutically-acceptable salts thereof, the use in therapy and pharmaceutical compositions and methods of treatment using the same.