66917-18-8 Usage
Uses
Used in Pharmaceutical Industry:
6-Cyano-1,2,3,5-tetrahydro-7-Methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester is used as an intermediate in the preparation of Camptothecin derivatives for their therapeutic use as antitumor agents. Camptothecins are a class of alkaloids that exhibit potent anticancer properties by inhibiting the enzyme topoisomerase I, which is essential for DNA replication and transcription. 6-Cyano-1,2,3,5-tetrahydro-7-Methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester plays a crucial role in the development of novel cancer therapies and contributes to the advancement of cancer treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 66917-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,1 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66917-18:
(7*6)+(6*6)+(5*9)+(4*1)+(3*7)+(2*1)+(1*8)=158
158 % 10 = 8
So 66917-18-8 is a valid CAS Registry Number.
66917-18-8Relevant academic research and scientific papers
Process for the preparation of tetrahydroindolizines
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Example 7, (2010/01/30)
Described is a process for the preparation of Compound (7) in accordance with the following reaction scheme by reacting Compound (5) with ethylene glycol in a solvent in the presence of a Lewis acid, thereby obtaining Compound (6), and then reacting the resulting compound with a carbonate diester in a solvent in the presence of a metal alkoxide (R1, R6each represents a C1-6alkyl group or the like and R5represents H or C1-5alkyl group). Compound (7) so obtained is useful as an intermediate for camptothecins useful as antitumor agents.
