66917-18-8 Usage
Chemical Properties
6-Cyano-1,2,3,5-tetrahydro-7-Methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester is Pink Solid
Uses
Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents.
Check Digit Verification of cas no
The CAS Registry Mumber 66917-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,1 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66917-18:
(7*6)+(6*6)+(5*9)+(4*1)+(3*7)+(2*1)+(1*8)=158
158 % 10 = 8
So 66917-18-8 is a valid CAS Registry Number.
66917-18-8Relevant articles and documents
Process for the preparation of tetrahydroindolizines
-
Example 7, (2010/01/30)
Described is a process for the preparation of Compound (7) in accordance with the following reaction scheme by reacting Compound (5) with ethylene glycol in a solvent in the presence of a Lewis acid, thereby obtaining Compound (6), and then reacting the resulting compound with a carbonate diester in a solvent in the presence of a metal alkoxide (R1, R6each represents a C1-6alkyl group or the like and R5represents H or C1-5alkyl group). Compound (7) so obtained is useful as an intermediate for camptothecins useful as antitumor agents.
