66948-38-7

Usage

Structure

A five-membered aromatic ring with two nitrogen atoms at positions 1 and 3, with a phenylmethyl group attached to the 4-position of the ring.

Properties

Unique properties and biological activities due to the presence of the phenylmethyl group.

Pharmaceutical applications

Studied for its potential use as a building block for the synthesis of pharmaceutical drugs and as a ligand in coordination chemistry.

Materials science

Investigated for its potential use in materials science.

Precursor

Used as a precursor for the synthesis of various organic compounds.

Upstream product

• 30457-88-6 2-benzyl-2-propenal 
• 100-39-0 benzyl bromide 
• 1867-37-4 Benzylmalononitrile 
• 109547-60-6 4-benzyl-1H-pyrazole-3,5-diamine 
• 37599-31-8 4-(α-hydroxybenzyl)pyrazole 

Downstream Products

• 1385068-84-7 1,4-dibenzyl-1H-pyrazole 
• 1385068-86-9 (4-benzyl-1H-pyrazol-1-yl)(phenyl)methanone 
• 1385068-87-0 4-benzyl-1-ethyl-1H-pyrazole 
• 1385068-89-2 1-allyl-4-benzyl-1H-pyrazole 
• 1385068-91-6 4-benzyl-1-(prop-2-yn-1-yl)-1H-pyrazole 
• 1392498-68-8 4-benzyl-1-(trifluoromethyl)-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis of 4-benzylpyrazoles from monobenzylmalononitrile

The hitherto unknown 4-benzylpyrazoles can be prepared in three steps by monobenzylation of malononitrile, reaction with hydrazines to form 3,5-diamino-4-benzylpyrazoles, followed by double deamination.

FUSED RING HETEROARYL COMPOUNDS AS RIPK1 INHIBITORS

The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided c

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.

Synthesis of 4-Alkylpyrazoles from 3,5-Diaminopyrazoles

The possibility of preparing 4-alkylpyrazole from malononitrile (through C-alkyl malononitriles and 3,5-diamino-4-alkylpyrazoles) has been explored.Although some difficulties arise in the double-deamination step, the method has allowed the synthesis of 4-benzyl-and 4-phenyl-pyrazoles.New 3-halogenopyrazoles have also been prepared.The synthesis of 3,5-diamino-4-iodopyrazole is reported.This elusive compound has a 13C NMR spectrum in which an aromatic carbon (C-4) appears at δ 29,53.

Synthetic inhibitors of alcohol dehydrogenase. Pyrazoles containing an unsaturated hydrocarbon residue in the 4-position.

A series of pyrazoles containing an unsaturated hydrocarbon residue in the 4-position has been synthesized and tested for ability to inhibit the activity of the enzyme liver alcohol dehydrogenase. These compounds were found to be less active than the corr