66971-55-9

Usage

InChI:InChI=1/C5H9N5O2/c1-3-4(10(11)12)5(7-6)9(2)8-3/h7H,6H2,1-2H3

Upstream product

• 76689-62-8 5-bromo-1,3-dimethyl-4-nitropyrazole 
• 54454-10-3 5-chloro-1,3-dimethyl-pyrazole 
• 13551-73-0 5-chloro-1,3-dimethyl-4-nitro-1H-pyrazole 

Downstream Products

• 960502-50-5 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)-4-methylbenzohydrazide 
• 960502-53-8 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)-2-furohydrazide 
• 383396-18-7 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)benzohydrazide 
• 869300-88-9 5-[(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 3920-38-5 1,3-dimethyl-4-nitro-1H-pyrazole 
• 1217131-83-3 4-chlorobenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 304877-27-8 benzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 300805-79-2 4-hydroxybenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 1217131-82-2 2,3-dimethoxybenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 960502-54-9 N'-(4-amino-1,3-dimethyl-1H-pyrazol-5-yl)-4-methylbenzohydrazide 

Relevant academic research and scientific papers

Synthesis and cytotoxic activity of some new bipyrazole derivatives

A new series of bipyrazole derivatives were prepared and characterized via the reaction of 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole with various 1,3-dicarbonyl compounds. The synthetic pathway was based on the classical Knorr pyrazole synthesis. In vitro cytotoxic activity of the fully characterized bipyrazole derivatives was determined and their IC50 values were also reported.

Synthesis, crystal structure, spectroscopic and computational studies of 2-{1-[2-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]ethyl}pyridine

2-{1-[2-(1,3-Dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]ethyl}-pyridine has been prepared from 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole and 2-acetylpyridine in an ethanolic solution. It crystallizes as an (E/Z) isomeric pair in the triclinic space group P-1 with the lattice parameters: a = 10.357(1) ?, b = 11.613(1) ?, c = 13.069(1) ?, α = 67.74(1)°, β = 70.77(1)°, γ = 67.92(1)°, volume = 1315.6(3) ?3, Z = 2. The isomeric pair (E/Z) is contained in the unit cell, where the N-H group is H-bonded to the pyridine nitrogen and to the oxygen of the nitro group in the Z-isomer and to the oxygen of the nitro group only in the E-isomer. NMR showed that the E-isomer is the major. DFT calculations were performed to further investigate the electronic properties of the synthesized compound.

Synthesis of 5-substituted 1,3-dimethylpyrazolo[4,3-e][1,2,4]triazines

A novel method for the synthesis of a new series of 5-substituted 1,3-dimethyl pyrazolo[4,3-e][1,2,4]triazines is described. The new synthetic strategy is based on the classical Bischler 1,2,4-benzotriazine synthesis. This approach involves the preparatio

5-Substituted derivatives of dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acids and esters

New 5-substituted derivatives of dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, esters and their salts have the formula STR1 R1 is hydrogen, lower alkyl or phenyl-lower alkylene; R2 and R3 each is hydrogen or lower alkyl; X is oxygen or sulfur; and R4 is hydrogen, lower alkyl, phenyl-lower alkylene or amino-lower alkylene. The new compounds are useful as anti-inflammatory agents and immunosuppressive agents.