6701-82-2Relevant academic research and scientific papers
Compositions containing ionic liquids and their uses, in particular in organic synthesis
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Page/Page column 30, (2016/10/17)
An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.
Onium salt supported peptide synthesis
Roche, Céline,Pucheault, Mathieu,Vaultier, Michel,Commeron, Alain
experimental part, p. 8325 - 8334 (2010/11/03)
Task specific ionic liquids and onium salts have been used as soluble supports for peptide synthesis. These new supports combine easy monitoring, high loading capacities, large scale preparation, and homogeneous kinetics characteristics while keeping adva
Use of functionalized onium salts as a soluble support for organic synthesis
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Page/Page column 32, (2010/11/25)
The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.
Task specific onium salts (TSOSs) as efficient soluble supports for Zard radical addition to olefins
Verron, Julien,Joerger, Jean-Michel,Pucheault, Mathieu,Vaultier, Michel
, p. 4055 - 4058 (2008/02/03)
Task specific onium salts (TSOSs), that is, functionalised ammonium salts, have been used as soluble supports to carry out intermolecular radical additions of xanthates to olefins and functional group interconversions. This methodology provides results by
Reaction rates as a function of scale within ionic liquids: Microscale in droplet microreactors versus macroscale reactions in the case of the grieco three-component condensation reaction
Dubois, Philippe,Marchand, Gilles,Gmouh, Said,Vaultier, Michel
, p. 5642 - 5648 (2008/02/13)
Task-specific ionic liquids (TSILs) and more specifically binary task-specific ionic liquids (BTSILs), a unique subclass, have been shown to be excellent supports for solution-phase chemistry. The negligible volatility of ionic liquids enables their use a
Ionic liquid droplet as e-microreactor
Dubois, Philippe,Marchand, Gilles,Fouillet, Yves,Berthier, Jean,Douki, Thierry,Hassine, Fatima,Gmouh, Said,Vaultier, Michel
, p. 4909 - 4917 (2008/02/12)
A powerful approach combining a droplet-based, open digital microfluidic lab-on-a-chip using task-specific ionic liquids as soluble supports to perform solution-phase synthesis is reported as a new tool for chemical applications. The negligible volatility of ionic liquids enables their use as stable droplet reactors on a chip surface under air. The concept was validated with different ionic liquids and with a multicomponent reaction. Indeed, we showed that different ionic liquids can be moved by electrowetting on dielectric (EWOD), and their displacement was compared with aqueous solutions. Furthermore, we showed that mixing ionic liquids droplets, each containing a different reagent, in "open" systems is an efficient way of carrying supported organic synthesis. This was applied to Grieco's tetrahydroquinolines synthesis with different reagents. Analysis of the final product was performed off-line and on-line, and the results were compared with those obtained in a conventional reaction flask. This technology opens the way to easy synthesis of minute amounts of compounds ad libitum without the use of complex, expensive, and bulky robots and allows complete automation of the process for embedded chemistry in a portable device. It offers several advantages, including simplicity of use, flexibility, and scalability, and appears to be complementary to conventional microfluidic lab-on-a-chip devices usually based on continuous-flow in microchannels.
