67010-09-7

Basic information

• Product Name: n-acetyl-5-Methoxy-l-tryptophan
• Synonyms: n-acetyl-5-Methoxy-l-tryptophan;Ac-L-5-methoxytryptophan;(S)-2-Acetamido-3-(5-methoxy-1H-indol-3-yl)propanoic acid
• CAS NO: 67010-09-7
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.28784
• Mol File: 67010-09-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 608.8°Cat760mmHg
• Flash Point: 322°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 1.12E-15mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• CAS DataBase Reference: n-acetyl-5-Methoxy-l-tryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: n-acetyl-5-Methoxy-l-tryptophan(67010-09-7)
• EPA Substance Registry System: n-acetyl-5-Methoxy-l-tryptophan(67010-09-7)

Safety Data

• Hazardous Substances Data: 67010-09-7(Hazardous Substances Data)

Usage

General Description

"N-acetyl-5-Methoxy-l-tryptophan" is a chemical compound that is a derivative of the amino acid tryptophan. It is often used as a precursor in the synthesis of serotonin, a neurotransmitter that plays a crucial role in regulating mood, appetite, and sleep. Additionally, it has been studied for its potential therapeutic effects in treating depression, anxiety, and other mood disorders. The acetyl group attached to the molecule helps to increase its bioavailability and absorption in the body, making it a promising candidate for various pharmaceutical applications. Overall, "n-acetyl-5-Methoxy-l-tryptophan" has shown potential as a valuable compound for improving mental health and overall well-being.

InChI:InChI=1/C14H16N2O4/c1-8(17)16-13(14(18)19)5-9-7-15-12-4-3-10(20-2)6-11(9)12/h3-4,6-7,13,15H,5H2,1-2H3,(H,16,17)(H,18,19)

Upstream product

• 108-24-7 acetic anhydride 
• 25197-96-0 5-methoxy-DL-tryptophan 
• 54744-68-2 acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid 
• 54744-69-3 acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester 
• 16620-52-3 5-methoxygramine 
• 1006-94-6 5-methoxylindole 
• 68-95-1 (S)-acetylproline 
• 147-85-3 L-proline 
• 154005-67-1 (S)-1-Acetyl-5-hydroxy-pyrrolidine-2-carboxylic acid methyl ester 
• 2311-25-3 N-acetyl-L-proline methyl ester 
• 93272-00-5 5-methoxy-N_b-acetyl-L-tryptophan methyl ester 

Downstream Products

• 2504-22-5 5-methoxy-L-tryptophan 

Relevant articles and documents

5-METHOXYTRYPTOPHAN AND ITS DERIVATIVES AND USES THEREOF

A 5-methoxytryptophan and its derivatives are disclosed, wherein the 5-methoxytryptophan and its derivatives are represented by the following formula (I): (I) wherein R1, R2, R3, R4, R5, and n are defined in the specification. In addition, the present invention also provides novel used of the 5-methoxytryptophan and its derivatives for treating inflammatory-related disease and cancers.

Syntheses of Substituted L- and D-Tryptophans

Several 5-substituted nb-methoxycarbonyl-L- and -D-tryptophan derivatives were synthesized from proline by a new route involving electrochemical oxidation, as well as by the known procedures.Removal of the Nb-methoxycarbonyl group was accomplished by treatment with Me3SiI in refluxing chloroform, then alkaline hydrolysis of the methyl esters afforded 5-substituted L- and D-tryptophans with high optical purities.Keywords - L-tryptophan 5-substituted; D-tryptophan 5-substituted; anodic oxidation; N-methoxycarbonyl group deprotection; Fischer indole synthesis; iodotrimethylsilane