67010-10-0Relevant academic research and scientific papers
Dipeptides of L-5-hydroxytryptophan, processes for their preparation and drugs in which they are present
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, (2008/06/13)
The present invention relates to new dipeptides of L-5-hydroxytryptophan. They correspond to the general formula below: STR1 in which: X represents hydrogen or a lower acyl radical and Q represents a free or esterified aminoacid radical. Application: drugs for combating disorder of the serotoninergic system.
Syntheses of Substituted L- and D-Tryptophans
Irie, Kunihiko,Ishida, Akihiko,Nakamura, Tohru,Oh-ishi, Tokuro
, p. 2126 - 2139 (2007/10/02)
Several 5-substituted nb-methoxycarbonyl-L- and -D-tryptophan derivatives were synthesized from proline by a new route involving electrochemical oxidation, as well as by the known procedures.Removal of the Nb-methoxycarbonyl group was accomplished by treatment with Me3SiI in refluxing chloroform, then alkaline hydrolysis of the methyl esters afforded 5-substituted L- and D-tryptophans with high optical purities.Keywords - L-tryptophan 5-substituted; D-tryptophan 5-substituted; anodic oxidation; N-methoxycarbonyl group deprotection; Fischer indole synthesis; iodotrimethylsilane
