670220-82-3Relevant academic research and scientific papers
Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups
Wang, Shao-Rong,Yang, Chun-Gang,Sánchez-Murcia, Pedro A.,Snyder, James P.,Yan, Ning,Sáez-Calvo, Gonzalo,Díaz, José Fernando,Gago, Federico,Fang, Wei-Shuo
, p. 6098 - 6101 (2015)
To probe the exact role of the oxetane D ring in both tubulin binding and cytotoxicity of taxanes, novel D-seco taxanes bearing a C4 ether substituent have been prepared from paclitaxel 1a. Among them, 20-hydroxymethyl-4-allyloxy D-seco taxane 5e is the m
Synthesis, Modeling, and Anti-Tubulin Activity of a D-Seco Paclitaxel Analogue
Barboni, Luciano,Giarlo, Guido,Ricciutelli, Massimo,Ballini, Roberto,Georg, Gunda I.,VanderVelde, David G.,Himes, Richard H.,Wang, Minmin,Lakdawala, Ami,Snyder, James P.
, p. 461 - 464 (2007/10/03)
(Equation presented) We have previously described a model of paclitaxel-microtubule binding that led to the prediction that analogues of paclitaxel lacking any D ring could stabilize microtubules as well as paclitaxel if the substituent present at C4 did
