67029-82-7

Basic information

• Product Name: 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone
• Synonyms: 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone
• CAS NO: 67029-82-7
• Molecular Formula: C₁₂H₉BrO₂
• Molecular Weight: 265.10266
• Mol File: 67029-82-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone(67029-82-7)
• EPA Substance Registry System: 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone(67029-82-7)

Safety Data

• Hazardous Substances Data: 67029-82-7(Hazardous Substances Data)

Usage

General Description

2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone is a chemical compound with the molecular formula C12H9BrO2. It is a brominated ketone derivative of 2-hydroxynaphthalene, containing a bromine atom and a carbonyl group attached to a naphthalene ring. 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone is primarily used in organic synthesis and pharmaceutical research as a building block for the development of various drug candidates. It may also be used as a reagent in chemical reactions to introduce specific functionalities into organic molecules. Additionally, it is important to handle this chemical with proper care and adhere to safety guidelines due to its potential hazards and toxicity.

Upstream product

• 711-79-5 1-hydroxy-2-acetonaphthone 
• 35085-58-6 1-(1-acetyloxynaphthalen-2-yl)ethanone 
• 828276-32-0 2-bromo-1-(1-acetyloxynaphthalen-2-yl)ethanone 

Downstream Products

• 80309-01-9 ω,4-dibromo-2-acetyl-1-naphthol 

Relevant articles and documents

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C-H bond cleavage-enabled aerobic ring-opening reaction of: In situ formed 2-aminobenzofuran-3(2 H)-ones

A C-H bond cleavage-enabled aerobic ring-opening reaction of 2-aminobenzofuran-3(2H)-ones formed in situ by hemiacetals with a variety of amines is reported. This simple one-pot reaction provides an alternative approach to obtain o-hydroxyaryl glyoxylamides in excellent yields of up to 97%. Alkylamines react with hemiacetals via a catalyst-free dehydration condensation to generate 2-aminobenzofuran-3(2H)-ones. The in situ formed semicyclic N,O-acetals undergo the same amine-initiated C-H bond hydroxylation in air under mild conditions to afford ring-opening products. Similarly, arylamines were investigated as substrates for a two-step tandem process involving a DPP-catalyzed condensation followed by a Et2NH-mediated C-H hydroxylation. Unlike the previously reported functionalization of N,O-acetals via a C-O or C-N cleavage, the aerobic oxidative C-H hydroxylation in this reaction, which is promoted by using stoichiometric amounts of alkylamines as both a Lewis base and a reductant at room temperature under atmospheric air, proceeds via α-carbonyl-stabilized carbanion intermediates from the C-H cleavage of N,O-acetals. This journal is