67029-82-7

Usage

Uses

Used in Organic Synthesis:
2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone is used as a building block in organic synthesis for the development of various chemical compounds. Its unique structure allows for the introduction of specific functionalities into organic molecules, facilitating the creation of new and diverse chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone serves as a key intermediate in the synthesis of drug candidates. Its presence in these compounds can contribute to their biological activity and therapeutic potential, making it a valuable component in the development of new medications.
Used as a Reagent in Chemical Reactions:
2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone is also utilized as a reagent in chemical reactions to introduce specific functionalities into organic molecules. Its reactivity and structural features make it a useful tool for chemists in various synthetic processes.
Safety Considerations:
It is important to handle 2-bromo-1-(1-hydroxynaphthalen-2-yl)ethanone with proper care and adhere to safety guidelines due to its potential hazards and toxicity. Appropriate protective measures should be taken to minimize risks associated with its use in research and industrial applications.

Upstream product

• 828276-32-0 2-bromo-1-(1-acetyloxynaphthalen-2-yl)ethanone 
• 711-79-5 1-hydroxy-2-acetonaphthone 
• 35085-58-6 1-(1-acetyloxynaphthalen-2-yl)ethanone 

Downstream Products

• 80309-01-9 ω,4-dibromo-2-acetyl-1-naphthol 

Relevant academic research and scientific papers

MeONH 2·hCl-Mediated α-Methylenation/Conjugate Addition of α-Sulfonylo-Hydroxyacetophenones with Methyl Sulfoxides: Route to 3-Sulfonylchroman-4-ones

A novel and efficient route for the synthesis of 3-sulfonylchroman-4-ones from α-sulfonyl o -hydroxyacetophenones with methyl sulfoxides via a MeONH 2·HCl-mediated sequential methylenation/ conjugate addition is described. Plausible reaction mechanisms are proposed and discussed. Various reaction conditions for this novel, one-pot, environmentally friendly conversion were investigated.

C-H bond cleavage-enabled aerobic ring-opening reaction of: In situ formed 2-aminobenzofuran-3(2 H)-ones

A C-H bond cleavage-enabled aerobic ring-opening reaction of 2-aminobenzofuran-3(2H)-ones formed in situ by hemiacetals with a variety of amines is reported. This simple one-pot reaction provides an alternative approach to obtain o-hydroxyaryl glyoxylamides in excellent yields of up to 97%. Alkylamines react with hemiacetals via a catalyst-free dehydration condensation to generate 2-aminobenzofuran-3(2H)-ones. The in situ formed semicyclic N,O-acetals undergo the same amine-initiated C-H bond hydroxylation in air under mild conditions to afford ring-opening products. Similarly, arylamines were investigated as substrates for a two-step tandem process involving a DPP-catalyzed condensation followed by a Et2NH-mediated C-H hydroxylation. Unlike the previously reported functionalization of N,O-acetals via a C-O or C-N cleavage, the aerobic oxidative C-H hydroxylation in this reaction, which is promoted by using stoichiometric amounts of alkylamines as both a Lewis base and a reductant at room temperature under atmospheric air, proceeds via α-carbonyl-stabilized carbanion intermediates from the C-H cleavage of N,O-acetals. This journal is

Temperature-Controlled Desulfonylative Condensation of α-Sulfonyl o-Hydroxyacetophenones and 2-Formyl Azaarenes: Synthesis of Azaaryl Aurones and Flavones

Temperature-controlled intermolecular desulfonylative condensation of α-sulfonyl o-hydroxyacetophenones with 2-formyl azaarenes (pyridines and quinolones) provides azaaryl (pyridyl and quinolyl) aurones and flavones under warming and refluxing toluene reaction conditions via the formation of the intermediate of sulfonyl chroman-4-one. The uses of various solvents are investigated for facile and efficient transformation. A plausible mechanism is proposed.