67044-07-9Relevant academic research and scientific papers
A new synthesis of the cytotoxic alkaloid Luotonine A
Dallavalle, Sabrina,Merlini, Lucio
, p. 1835 - 1837 (2002)
A convenient synthesis of the cytotoxic alkaloid Luotonine A has been achieved using cheap and readily accessible reagents. The key intermediate in the synthesis is the tricyclic compound 2,3-dihydro[1H]-pyrrolo[3,4-b]quinolin-3-one (5).
SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE
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, (2020/12/11)
The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
Lewis acid-assisted olefin cross-metathesis reaction: An efficient approach for the synthesis of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin and evaluation of their antitumor activity
Nagarapu, Lingaiah,Gaikwad, Hanmant K.,Bantu, Rajashaker,Ganesh Kumar,Pombala, Sujitha
, p. 1287 - 1291 (2012/03/27)
A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin (2a-g) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti(OiPr)4 30 mol % and 10 mol % of Grubb's second generation catalyst with good to excellent yields. Most of these compounds exhibited significant growth inhibitory effects on all the tested cancer cell lines and three compounds (2c, 2d and 2e) showed potent cytotoxic activity.
Chemoenzymatic synthesis with lipase catalyzed resolution and evaluation of antitumor activity of (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H- pyrrolo[3,4-b]quinolin-3(2H)-one
Nagarapu, Lingaiah,Gaikwad, Hanmant K.,Bantu, Rajashaker,Manikonda, Sheeba Rani
, p. 2152 - 2156 (2011/06/21)
Synthesis, characterization, resolution and evaluation of novel (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H-pyrrolo[3,4-b] quinolin-3(2H)-one derivatives are described. Enantiomerically pure compounds were isolated in good to excellent yield w
