67073-72-7

Basic information

• Product Name: 3-BROMOBENZALDEHYDE DIMETHYL ACETAL
• Synonyms: 3-BROMOBENZALDEHYDE DIMETHYL ACETAL;1-bromo-3-(dimethoxymethyl)benzene;3-Bromobenzaldehyde dimethylaceta
• CAS NO: 67073-72-7
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.09
• EINECS: 266-563-1
• Product Categories: Adehydes, Acetals & Ketones;Bromine Compounds
• Mol File: 67073-72-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 231.3°Cat760mmHg
• Flash Point: 85°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 0.0951mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BROMOBENZALDEHYDE DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMOBENZALDEHYDE DIMETHYL ACETAL(67073-72-7)
• EPA Substance Registry System: 3-BROMOBENZALDEHYDE DIMETHYL ACETAL(67073-72-7)

Safety Data

• Hazardous Substances Data: 67073-72-7(Hazardous Substances Data)

Usage

General Description

3-Bromobenzaldehyde Dimethyl Acetal is a chemical compound widely used in the synthesis of various organic compounds. Its molecular formula is C10H11BrO2. This chemical is typically known for its high reactivity, making it beneficial in numerous applications in organic chemistry. The 3-Bromobenzaldehyde in dimethyl acetal form, allows it to be used as a protecting group for aldehydes during reactions in chemical synthesis procedures. As a specialty chemical, it is often utilized in research and development settings such as laboratories, and it requires standard safety handling procedures due to its potentially hazardous properties.

InChI:InChI=1/C9H11BrO2/c1-11-9(12-2)7-4-3-5-8(10)6-7/h3-6,9H,1-2H3

Upstream product

• 67-56-1 methanol 
• 3132-99-8 m-bromobenzoic aldehyde 
• 149-73-5 trimethyl orthoformate 
• 17789-14-9 3-(1,3-dioxolan-2-yl)-phenylbromide 

Downstream Products

• 134360-16-0 3-(N,N-dimethylthiocarbamoyl)benzaldehyde dimethyl acetal 
• 100501-45-9 3-(dimethoxymethyl)benzaldehyde 
• 241155-88-4 (E)-3-[2-(2-methoxyphenyl)ethenyl]benzaldehyde 
• 248589-09-5 (E,E)-3-[2-(2-methylphenyl)ethenyl]-N-phenylbenzaldimine 
• 540777-53-5 magnesium compound of 3-(dimethoxymethyl)bromobenzene 
• 158009-99-5 1,4-bis(3-formylphenyl)-1,4-dihydroxy-2,5-cyclohexadiene 
• 2972-74-9 2-(3-bromobenzylidene)malononitrile 
• 14394-73-1 (3-Brom-benzyliden)-cyanessigsaeure-aethylester 
• 1313397-54-4 5-(3-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)phenyl)isoindolin-1-one 
• 1313398-41-2 3-(1-oxoisoindolin-5-yl)benzaldehyde 
• 1313397-10-2 (E,Z)-5-(3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)benzylidene)-2-thioxoimidazolidin-4-one 
• 1313397-94-2 3-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)benzaldehyde 
• 1313397-93-1 5-(3-(dimethoxymethyl)phenyl)isobenzofuran-1(3H)-one 
• 619-21-6 m-formylphenyl benzoic acid 

Relevant articles and documents

Practical acetalization and transacetalization of carbonyl compounds catalyzed by recyclable PVP-I

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields.

Acid-catalyzed highly diastereoselective and effective synthesis of 1,3-disubstituted tetrahydropyrano[3,4-b]indoles

We successfully explored for the first time that trifluoroacetic acid (TFA) can effectively catalyze the oxa-Pictet-Spengler reaction of secondary tryptophols and acetals to synthesize 1,3-disubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indoles in high yield (up to >99%) and diastereoselectivity (>20:1). The secondary tryptophols were synthesized from indole-3-acetic acid. The one-pot synthesis of tetrahydropyrano[3,4-b]indoles was successfully developed from secondary tryptophols and in situ prepared acetals from aldehydes and trimethylorthoformate and thus the cost-efficiency of the protocol was effectively enhanced. Finally, the catalytic asymmetric synthesis of the 1,3-disubstituted tetrahydropyrano[3,4-b]indole was also demonstrated after enantioselective achievement of highly enantiopure secondary tryptophols.

Nanomolar β-lactamase inhibitors

New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acids, with Ki values as low as 1 nM.