67074-44-6

Basic information

• Product Name: Cyclopropanecarboxaldehyde, 2-phenyl- (9CI)
• Synonyms: Cyclopropanecarboxaldehyde, 2-phenyl- (9CI);Cyclopropanecarboxaldehyde, 2-phenyl-;2-phenylcyclopropane-1-carbaldehyde
• CAS NO: 67074-44-6
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.1858
• Product Categories: ALDEHYDE
• Mol File: 67074-44-6.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 240.6±29.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Cyclopropanecarboxaldehyde, 2-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxaldehyde, 2-phenyl- (9CI)(67074-44-6)
• EPA Substance Registry System: Cyclopropanecarboxaldehyde, 2-phenyl- (9CI)(67074-44-6)

Safety Data

• Hazardous Substances Data: 67074-44-6(Hazardous Substances Data)

Usage

General Description

Cyclopropanecarboxaldehyde, 2-phenyl- (9CI) is a chemical compound with the molecular formula C10H10O. It is a colorless liquid with a distinctive sweet, floral odor. It is commonly used in the production of fragrances, flavors, and pharmaceuticals. The compound is classified as an aldehyde, which means it contains a carbonyl group (C=O) bonded to a hydrogen atom and an R group. The specific 2-phenyl structure of this compound refers to a phenyl group (C6H5) attached to the second carbon of the cyclopropane ring. Due to its chemical properties and applications, cyclopropanecarboxaldehyde, 2-phenyl- (9CI) is an important compound in the chemical industry.

Upstream product

• 61826-40-2 (2-phenylcyclopropyl)methanol 
• 110659-58-0 (1S,2S)-trans-1-(hydroxymethyl)-2-phenylcyclopropane 
• 107804-91-1 ((1S,2R)-2-Dimethoxymethyl-cyclopropyl)-benzene 
• 33732-62-6 2-phenyl-2,3-dihydrofuran 
• 4510-34-3 (Z)-cinnamyl alcohol 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 107804-97-7 3-Dimethoxymethyl-5-phenyl-4,5-dihydro-3H-pyrazole 
• 100-42-5 styrene 
• 946-38-3 cis-1-ethoxycarbonyl-2-phenylcyclopropane 
• 100-52-7 benzaldehyde 
• 936-98-1 rac-((1S,2R)-2-phenylcyclopropyl)methanol 
• 73566-21-9 1-phenyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethan-1-one 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 1421259-31-5 C₂₇H₂₉N 

Downstream Products

• 121352-46-3 C₁₁H₉⁽²⁾H 
• 34271-31-3 trans-2-phenylcyclopropanecarbaldehyde 
• 161344-89-4 3E-<(1R,2S)-2-phenyl-1-cyclopropyl>-2-propen-1-ol 
• 161344-86-1 ethyl 3E-<(1R,2S)-2-phenyl-1-cyclopropyl>prop-1-enoate 
• 499115-34-3 (1S,2S)-methyl 3-(trans-2-phenylcyclopropyl) acrylate 
• 22467-91-0 cis-1-(trans-β-Ethoxycarbonylvinyl)-2-phenylcyclopropan 
• 625455-49-4 (1R,1’S,2’S)-1-(2-phenylcyclopropyl)but-3-en-1-ol 
• 625455-48-3 (1S,1’S,2’S)-1-(2-phenylcyclopropyl)but-3-en-1-ol 
• 823180-02-5 (2-(2,2-diiodovinyl)cyclopropyl)benzene 
• 679429-87-9 1-((1S,2S)-2-Phenyl-cyclopropyl)-but-3-en-1-one 

Relevant articles and documents

Donor-Acceptor Bicyclopropyls as 1,6-Zwitterionic Intermediates: Synthesis and Reactions with 4-Phenyl-1,2,4-triazoline-3,5-dione and Terminal Acetylenes

The bicyclopropyl system activated by incorporation of donor and acceptor groups in the presence of Lewis acids was used as a synthetic equivalent of 1,6-zwitterions. Opening of both cyclopropane rings in 2′-aryl-1,1′-bicyclopropyl-2,2-dicarboxylates (D-A bicyclopropyl, ABCDs) in the presence of GaI3 + Bu4N+GaI4- results in 5-iodo-5-arylpent-2-enylmalonates as products of HI formal 1,6-addition to the bicyclopropyl system. The use of GaCl3 or GaBr3 as a Lewis acid and terminal aryl or alkyl acetylenes as 1,6-zwitterion interceptors allows the alkyl substituent to be grown to give the corresponding acyclic 7-chloro(bromo)-hepta-2,6-dienylmalonates. The reaction of ABCDs with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) catalyzed by Yb(OTf)3 also results in the opening of both cyclopropane rings. The reaction products are tetrahydropyridazine derivatives - (7,9-dioxo-1,6,8-triazabicyclo[4.3.0]non-3-en-2-ylmethyl)malonates - containing one more PTAD moiety in the malonyl group.

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived-growth-factor-p75 (LEDGF/p75)-binding site on HIV-1 integrase, an attractive target for antiviral chemotherapy, was prepared and screened for activity against HIV-1 infection in cell culture. Small molecules that bind within the LEDGF/p75-binding site promote aberrant multimerization of the integrase enzyme and are of significant interest as HIV-1-replication inhibitors. Structure-activity-relationship studies and rat pharmacokinetic studies of lead compounds are presented.

Copper(I)- and Mesoionic-Hydroxyamide-Catalyzed Chemoselective Aerobic Oxidation of Primary Benzylic Alcohols

A new aerobic oxidation system consisting of Cu(I)I, 2,2'-bipyridine, N -methyl imidazole, and a mesoionic hydroxyamide was developed, with which selective oxidation of a broad range of benzylic alcohols was achieved.