67085-13-6

Usage

Uses

Used in Pharmaceutical Industry:
Butoconazole is used as an antifungal agent for the treatment of vaginal yeast infections. It is applied topically to the affected area, targeting and eliminating the fungi responsible for the infection. The medication is effective due to its ability to inhibit fungal growth and disrupt their cell membranes, leading to their eventual death. This makes Butoconazole a valuable asset in the management and treatment of vaginal yeast infections.

InChI:InChI=1/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2

Upstream product

• 67085-12-5 1-[2-chloro-4-(4-chlorophenyl)-n-butyl]imidazole 
• 24966-39-0 2,6-dichlorothiophenol 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 59363-13-2 1-chloro-4-(4-chlorophenyl)-2-butanol 
• 67085-11-4 1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole 
• 151837-98-8 Methanesulfonic acid (S)-3-(4-chloro-phenyl)-1-imidazol-1-ylmethyl-propyl ester 
• 151837-97-7 Methanesulfonic acid (R)-3-(4-chloro-phenyl)-1-imidazol-1-ylmethyl-propyl ester 
• 64872-76-0 butoconazole 
• 151837-95-5 (2R)-1-(p-toluenesulphonyloxy)-4-(4-chlorophenyl)butan-2-ol 
• 151909-78-3 (2R)-1-<2-hydroxy-4-(4-chlorophenyl)butyl>-1H-imidazole 
• 151837-96-6 (2S)-1-(p-toluenesulphonyloxy)-4-(4-chlorophenyl)butan-2-ol 
• 151909-79-4 (2S)-1-<2-hydroxy-4-(4-chlorophenyl)butyl>-1H-imidazole 
• 874-72-6 4-chlorobenzylmagnesium chloride 

Relevant academic research and scientific papers

Solid phase extraction procedure coupled with the chiral LC-ESI-MS/MS method for the enantioseparation and determination of butoconazole enantiomers in rat plasma and tissues: application to the enantioselective study on pharmacokinetics and tissue distribution

In the present study, a highly rapid, sensitive and enantioselective method was developed and fully validated for the separation and determination of butoconazole enantiomers in rat plasma and tissues by liquid chromatography-electrospray ionization coupled with tandem mass spectrometry (LC-ESI-MS/MS). The analytes and internal standard (tioconazole) were both extracted from plasma and tissue samples by the solid phase extraction (SPE) procedure with C18 cartridges. Satisfactory enantioseparation was achieved on a Chiralpak IC column by using acetonitrile/10 mM aqueous ammonium acetate (90?:?10, v/v) as a mobile phase. Butoconazole enantiomers and IS were detected in the multiple reaction monitoring (MRM) mode with a positive electrospray ionization source. A comprehensive validation of this method was conducted over the concentration range of 0.5-250 ng mL-1, and good linearity was obtained for each enantiomer with correlation coefficient (R2) greater than 0.991. The mean extraction recoveries were higher than 90.4%, and the relative error was well within the admissible range of -8.0 to 9.1% and the relative standard deviation was less than 11.5%. All the validation data demonstrated that the desirable specificity, carry-over, linearity, sensitivity, accuracy, precision, extraction recovery, matrix effect and stability were attained from the proposed approach. After validation, the established method was successfully applied to the study on stereoselective pharmacokinetics and tissue distribution in female Sprague-Dawley rats after transdermal administration of 10 mg kg-1 2% rac-butoconazole nitrate cream. It should be noted that this is the first report regarding the stereospecific study of butoconazole enantiomers in vivo. This journal is

HPLC method for separating enantiomers of imidazole derivatives - Antifungal compounds

The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tioconazole. The study was performed using HPLC method and the CHIRALCEL OJ column (10 μm; 250 × 4.6 mm), the mobile phase flow rate of 0.8 mL/min and detection at 220 nm. Mobile phases containing hexane and the following modifiers: alcohols (2-propanol, ethanol, methanol) and diethylamine were tested. At first isocratic elution was used but some enantiomers eluted after a long retention time and their peaks were asymmetrical and too wide. Therefore, a gradient elution was developed allowing to obtain satisfactory retention times and other parameters of enentioseparation of the compounds.

Preparation method of butoconazole nitrate

The invention discloses a preparation method of butoconazole nitrate. The preparation method comprises the following steps: with 4-chlorobenzyl chloride as a starting raw material, synthesizing 1-chloro-4-(4-chlorophenyl)-2-butanol, then synthesizing 1-(4-(4-chlorophenyl)-2-hydroxy-butyl) imidazole, then synthesizing 1-(4-(4-chlorophenyl)-2-chloro-butyl) imidazole, adding the 1-(4-(4-chlorophenyl)-2-chloro-butyl) imidazole, 2, 6-dichlorobenzenethiol and potassium carbonate into acetone, heating for refluxing, adding water and ethyl acetate after the completion of a reaction, performing liquid separation, sequentially washing an ethyl acetate phase by using saturated potassium carbonate and saturated salt water, drying by using anhydrous magnesium sulfate, removing magnesium sulfate, dropwise adding nitric acid with the concentration of 65% in an ice bath until no precipitate is produced, filtering for collecting solid, and recrystallizing by using absolute ethanol to obtain white crystals, namely the butoconazole nitrate. By the preparation method of the butoconazole nitrate, the process is simple, the yield is high, the cost is low, and the purity of the obtained product is high.

The Synthesis and Antifungal Activity of the Enantiomers of Butoconazole Nitrate

The S and R enantiomers 2 and 3 of the antifungal agent butoconazole nitrate have been prepared in optically pure form, in three steps, from R- and S-glycidyl tosylates 4 and 5 respectively.No significant difference was found in the in vitro activity of butoconazole and its enantiomers versus Candida albicans.