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67085-13-6

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67085-13-6 Usage

Description

Butoconazole is a broad-spectrum antifungal medication primarily used for the treatment of vaginal yeast infections. It functions by inhibiting fungal growth and disrupting their cell membranes, which ultimately leads to the death of the fungi. Butoconazole is available in the form of a topical cream and is generally well-tolerated with minimal side effects, making it a safe and effective treatment option.

Uses

Used in Pharmaceutical Industry:
Butoconazole is used as an antifungal agent for the treatment of vaginal yeast infections. It is applied topically to the affected area, targeting and eliminating the fungi responsible for the infection. The medication is effective due to its ability to inhibit fungal growth and disrupt their cell membranes, leading to their eventual death. This makes Butoconazole a valuable asset in the management and treatment of vaginal yeast infections.

Check Digit Verification of cas no

The CAS Registry Mumber 67085-13-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,0,8 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67085-13:
(7*6)+(6*7)+(5*0)+(4*8)+(3*5)+(2*1)+(1*3)=136
136 % 10 = 6
So 67085-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2

67085-13-6Downstream Products

67085-13-6Relevant articles and documents

Solid phase extraction procedure coupled with the chiral LC-ESI-MS/MS method for the enantioseparation and determination of butoconazole enantiomers in rat plasma and tissues: application to the enantioselective study on pharmacokinetics and tissue distribution

Ma, Siman,Wang, Lina,Guo, Guoxian,Yu, Jia,Guo, Xingjie

, p. 1317 - 1326 (2021)

In the present study, a highly rapid, sensitive and enantioselective method was developed and fully validated for the separation and determination of butoconazole enantiomers in rat plasma and tissues by liquid chromatography-electrospray ionization coupled with tandem mass spectrometry (LC-ESI-MS/MS). The analytes and internal standard (tioconazole) were both extracted from plasma and tissue samples by the solid phase extraction (SPE) procedure with C18 cartridges. Satisfactory enantioseparation was achieved on a Chiralpak IC column by using acetonitrile/10 mM aqueous ammonium acetate (90?:?10, v/v) as a mobile phase. Butoconazole enantiomers and IS were detected in the multiple reaction monitoring (MRM) mode with a positive electrospray ionization source. A comprehensive validation of this method was conducted over the concentration range of 0.5-250 ng mL-1, and good linearity was obtained for each enantiomer with correlation coefficient (R2) greater than 0.991. The mean extraction recoveries were higher than 90.4%, and the relative error was well within the admissible range of -8.0 to 9.1% and the relative standard deviation was less than 11.5%. All the validation data demonstrated that the desirable specificity, carry-over, linearity, sensitivity, accuracy, precision, extraction recovery, matrix effect and stability were attained from the proposed approach. After validation, the established method was successfully applied to the study on stereoselective pharmacokinetics and tissue distribution in female Sprague-Dawley rats after transdermal administration of 10 mg kg-1 2% rac-butoconazole nitrate cream. It should be noted that this is the first report regarding the stereospecific study of butoconazole enantiomers in vivo. This journal is

HPLC method for separating enantiomers of imidazole derivatives - Antifungal compounds

Podolska, Marzena,Bia?ecka, Wanda,Kulik, Anna,Kwiatkowska-Puchniarz, Barbara,Mazurek, Aleksander

, p. 777 - 784 (2017/06/05)

The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tioconazole. The study was performed using HPLC method and the CHIRALCEL OJ column (10 μm; 250 × 4.6 mm), the mobile phase flow rate of 0.8 mL/min and detection at 220 nm. Mobile phases containing hexane and the following modifiers: alcohols (2-propanol, ethanol, methanol) and diethylamine were tested. At first isocratic elution was used but some enantiomers eluted after a long retention time and their peaks were asymmetrical and too wide. Therefore, a gradient elution was developed allowing to obtain satisfactory retention times and other parameters of enentioseparation of the compounds.

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