67087-52-9Relevant academic research and scientific papers
Rhodium(III)-Catalyzed C?H Alkynylation of N-Methylsulfoximines
Wang, Tao,Wang, Yi-Ning,Wang, Rui,Wang, Xi-Sheng
, p. 2449 - 2452 (2018/08/17)
A rhodium(III)-catalyzed direct C?H alkynylation of a wide range of N-methylsulfoximines with (bromoethynyl)triisopropylsilane has been developed. This protocol is compatible with both (S,S)-diaryl sulfoximines and (S,S)-alkyl aryl sulfoximines, and shows mild conditions, and good functional group tolerance. The synthetic utility of this method has been demonstrated by subsequent various transformations of the products.
Copper promoted: N -alkylation of sulfoximines with alkylboronic acid under mild conditions
Gupta, Surabhi,Chaudhary, Priyanka,Muniyappan, Nalluchamy,Sabiah, Shahulhameed,Kandasamy, Jeyakumar
supporting information, p. 8493 - 8498 (2017/10/27)
The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive l-methionine sulfoximine derivative was demonstrated under standard reaction conditions.
Direct Access to N -Alkylsulfoximines from Sulfides by a Sequential Imidation/Oxidation Procedure
Dannenberg, Carl Albrecht,Bizet, Vincent,Bolm, Carsten
, p. 1951 - 1959 (2015/06/30)
Synthetically relevant N-alkyl-substituted sulfoximines are directly prepared from sulfides by an unprecedented one-pot imidation/oxidation sequence. In situ generated N-bromoalkylamines serve as readily accessible imidating agents leading to N-alkylsulfiliminium bromides that are subsequently oxidized providing the corresponding N-alkylsulfoximines. In this manner, gram quantities of the products can be obtained in a short period of time avoiding the use of toxic and cumbersome to handle alkylating reagents.
