67127-83-7

Basic information

• Product Name: Benzoic acid, 3-formyl-2-hydroxy-5-methyl-
• CAS NO: 67127-83-7
• Molecular Formula: C9H8O4
• Molecular Weight: 180.16
• Mol File: 67127-83-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-formyl-2-hydroxy-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-formyl-2-hydroxy-5-methyl-(67127-83-7)
• EPA Substance Registry System: Benzoic acid, 3-formyl-2-hydroxy-5-methyl-(67127-83-7)

Safety Data

• Hazardous Substances Data: 67127-83-7(Hazardous Substances Data)

Upstream product

• 89-56-5 5-Methylsalicylic acid 
• 100-97-0 hexamethylenetetramine 
• 67-66-3 chloroform 
• 65448-72-8 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde 

Downstream Products

• 67127-85-9 3-cyano-5-methylsalicylic acid 
• 1074213-38-9 3-((2-octanoylhydrazono)methyl)-5-methylsalicylic acid 
• 721422-68-0 C₁₃H₁₆O₆ 
• 4186-88-3 3-Formyl-5-methyl-salicylsaeure-methylester 

Relevant articles and documents

Observation by NMR of the tautomerism of an intramolecular OHOHN-charge relay chain in a model Schiff base

As a model system for the internal and external aldimines of the coenzyme pyridoxal phosphate (PLP) in PLP dependent enzymes we have studied the 1H and 15N NMR spectra of the 15N labeled Schiff base 3-carboxy-5-methyl-salicylidenaniline (1) dissolved in CD2Cl2. 1 contains a charge relay system with two strongly coupled intramolecular hydrogen bonds of the OHOHN type. One-bond 15N{single bond}1H scalar spin-spin coupling constants and chemical shifts of partially deuterated 1 were measured in the temperature range between 243 and 183 K and analyzed assuming an exchange between three tautomeric states exhibiting well defined hydrogen bond geometries. The analysis shows that the dominant structure 1b corresponds to the zwitterion O{single bond}H?O-?H{single bond}N+, where deuteration of one bond leads to a shortening of the other. This anti-cooperative effect is revealed by the vicinal isotope effects on the proton chemical shifts. By contrast, forms 1a and 1c are characterized by the structures O{single bond}H?O{single bond}H?N and O-?H{single bond}O?H{single bond}N+, correspondingly, whose hydrogen bonds exhibit a cooperative coupling. We predict that 1a will dominate at high temperatures and low dielectric constants, whereas 1c will dominate at low temperatures and large dielectric constants. The comparison with model systems which do not contain the additional COOH-group indicates that the latter is responsible for the dominance of the zwitterionic structure of the OHN hydrogen bond. The implications of these findings for the function of the coenzyme pyridoxal phosphate in its natural environment are discussed.

LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO

Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein X, R1, Rs

A novel selective oxidation of 5-substituted 2-hydroxy-3-hydroxymethylbenzaldehydes

5-Substituted 2-hydroxy-1,3-benzenedicarbaldehydes 3 and 5-substituted 3-formyl-2-hydroxbenzoic acids 4 were prepared by selective oxidation of 5-substituted 2-hydroxy-3-(hydroxymethyl)-benzaldehydes 1 in a one-pot reaction. Compounds 1 were reacted with ethylenediamine and copper acetate to produce the complexes 2 as intermediates, in which formyl and phenolic hydroxy groups were protected in the subsequent oxidation step.