67127-83-7

Upstream product

• 67-66-3 chloroform 
• 89-56-5 5-Methylsalicylic acid 
• 100-97-0 hexamethylenetetramine 
• 65448-72-8 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde 

Downstream Products

• 4186-88-3 3-Formyl-5-methyl-salicylsaeure-methylester 
• 67127-85-9 3-cyano-5-methylsalicylic acid 
• 1074213-38-9 3-((2-octanoylhydrazono)methyl)-5-methylsalicylic acid 
• 721422-68-0 C₁₃H₁₆O₆ 

Relevant academic research and scientific papers

Observation by NMR of the tautomerism of an intramolecular OHOHN-charge relay chain in a model Schiff base

As a model system for the internal and external aldimines of the coenzyme pyridoxal phosphate (PLP) in PLP dependent enzymes we have studied the 1H and 15N NMR spectra of the 15N labeled Schiff base 3-carboxy-5-methyl-salicylidenaniline (1) dissolved in CD2Cl2. 1 contains a charge relay system with two strongly coupled intramolecular hydrogen bonds of the OHOHN type. One-bond 15N{single bond}1H scalar spin-spin coupling constants and chemical shifts of partially deuterated 1 were measured in the temperature range between 243 and 183 K and analyzed assuming an exchange between three tautomeric states exhibiting well defined hydrogen bond geometries. The analysis shows that the dominant structure 1b corresponds to the zwitterion O{single bond}H?O-?H{single bond}N+, where deuteration of one bond leads to a shortening of the other. This anti-cooperative effect is revealed by the vicinal isotope effects on the proton chemical shifts. By contrast, forms 1a and 1c are characterized by the structures O{single bond}H?O{single bond}H?N and O-?H{single bond}O?H{single bond}N+, correspondingly, whose hydrogen bonds exhibit a cooperative coupling. We predict that 1a will dominate at high temperatures and low dielectric constants, whereas 1c will dominate at low temperatures and large dielectric constants. The comparison with model systems which do not contain the additional COOH-group indicates that the latter is responsible for the dominance of the zwitterionic structure of the OHN hydrogen bond. The implications of these findings for the function of the coenzyme pyridoxal phosphate in its natural environment are discussed.

Polyacidic multiloading metal extractants

Novel polynucleating, di- and tri-acidic ligands have been designed to increase the molar and mass transport efficiencies for the recovery of base metals by solvent extraction. The Royal Society of Chemistry.

LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO

Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein X, R1, Rs

LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO

Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

A novel selective oxidation of 5-substituted 2-hydroxy-3-hydroxymethylbenzaldehydes

5-Substituted 2-hydroxy-1,3-benzenedicarbaldehydes 3 and 5-substituted 3-formyl-2-hydroxbenzoic acids 4 were prepared by selective oxidation of 5-substituted 2-hydroxy-3-(hydroxymethyl)-benzaldehydes 1 in a one-pot reaction. Compounds 1 were reacted with ethylenediamine and copper acetate to produce the complexes 2 as intermediates, in which formyl and phenolic hydroxy groups were protected in the subsequent oxidation step.

Benzamide derivatives

Benzamide derivatives of the formula:- STR1 wherein R1 represents a fluorine, chlorine or bromine atom, or an alkyl, alkoxy, alkylthio, alkylsulphonyl, alkanoylamino, alkylamino or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), an alkanoyl, alkoxycarbonyl, alkoxycarbonylamino or alkylcarbamoyl group containing from 2 to 6 carbon atoms, or a hydroxy, formyl, nitro, trifluoromethyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl or aroyl group, and n represents an integer 1, 2 or 3, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.