67135-97-1

Usage

Uses

Used in Fragrance Industry:
(2,4-dimethylphenyl)(phenyl)methanol is used as a fragrance ingredient for its floral, green, and balsamic scent in perfumes and personal care products.
Used in Cosmetic Products:
(2,4-dimethylphenyl)(phenyl)methanol is used as a key component in the production of soaps, detergents, and other cosmetic products due to its pleasant aroma.
Used in Food and Beverage Industry:
(2,4-dimethylphenyl)(phenyl)methanol is used as a flavoring agent to enhance the taste and aroma of food and beverages.
Used in Pharmaceutical Industry:
(2,4-dimethylphenyl)(phenyl)methanol is used as a building block in the synthesis of various drugs and pharmaceutical products, indicating its potential applications in this field.

Upstream product

• 109-72-8 n-butyllithium 
• 1140-14-3 2,4-Dimethyl benzophenone 
• 98-88-4 benzoyl chloride 
• 108-38-3 m-xylene 
• 15764-16-6 2,4-dimethylbenzaldehyde 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 613-12-7 2-methylanthracene 
• 65214-72-4 1-(chloro(phenyl)methyl)-2,4-dimethylbenzene 
• 518973-29-0 1-((2,4-dimethylphenyl)(phenyl)methyl)piperazine 

Relevant academic research and scientific papers

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR3 and (Ar1)2CR4 is optionally substituted benzhydryl.

Comparative Mechanistic Study of the Reaction of Benzophenone with n-BuMgBr and n-BuLi

Substituent effects on reactivity and product distribution (addition vs reduction) were determined for the reactions of benzophenones with n-BuMgBr and n-BuLi at 0 deg C.In case of the reaction with n-BuMgBr, meta and para-substituted benzophenones gave a reasonably linear Hammet plot, from which the ρ value of 1.45 was calculated, while ortho-substituted derivatives deviated downward from the correlation line.In contrast, the reaction with n-BuLi exhibit very small substituent effects on reactivity.The product distrubution is highly dependent on substituents in the n-BuMgBr reaction, whereas it is essentially independent of substituents in the n-BuLi reaction.Mechanistic differences between the reactions of these two reagents are discussed on the basis of these experimental results.

ASSYMETRIC REDUCTIONS OF KETONES USING LITHIUM ALUMINIUM HYDRIDE MODIFIED WITH N,N-DIALKYL DERIVATIVES OF (R)-(-)-2-AMINOBUTAN-1-OL

LiAlH4 previuosly treated with 2 equivalents of (R)-(-)-2-(2-iso-indolinyl)butan-1-ol (a readily available reagent) reduced 2-chloro and 2,4-dimethyl benzophenones into the corresponding benzhydrols with 100percent enantiomeric excess.Other examples of ketone reductions are given.